Document Detail


Acute myeloid leukemia associated with t(1;3)(p36;q21) and extreme thrombocytosis: a clinical study with literature review.
MedLine Citation:
PMID:  21156232     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We present an unusual case study on acute myeloid leukemia associated with t(1;3) and extreme thrombocytosis, along with a thorough review on relevant literature of t(1;3) cases (58 patients). On the basis of this study and literature review, thrombocytosis (>400,000/μL) is a relatively common finding in one third of patients with t(1;3), whereas increase of platelet count by more than 1,000,000/μL is an extremely rare phenomenon, even among patients with t(1;3). To our knowledge, this study is the only documented case that recorded more than 2,000,000/μL of extreme thrombocytosis in a de novo acute myeloid leukemia patient with t(1;3) at initial diagnosis. Because only a few patients with t(1;3) responded to conventional chemotherapy, more aggressive therapy such as stem-cell transplantation should be considered to improve patient survival in t(1;3) cases.
Authors:
Gayoung Lim; Min Jin Kim; Seung Hwan Oh; Sun Young Cho; Hee Joo Lee; Jin-Tae Suh; Juhie Lee; Woo-In Lee; Kyung Sam Cho; Tae Sung Park
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  203     ISSN:  1873-4456     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-15     Completed Date:  2011-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  187-92     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Affiliation:
Department of Laboratory Medicine, School of Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-702, Korea.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Bone Marrow Cells / cytology
Chromosomes, Human, Pair 1*
Chromosomes, Human, Pair 3*
Female
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Leukemia, Myeloid, Acute / genetics*
Male
Middle Aged
Thrombocytosis / genetics*
Translocation, Genetic*

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