| Acute myeloid leukemia associated with t(1;3)(p36;q21) and extreme thrombocytosis: a clinical study with literature review. | |
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MedLine Citation:
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PMID: 21156232 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We present an unusual case study on acute myeloid leukemia associated with t(1;3) and extreme thrombocytosis, along with a thorough review on relevant literature of t(1;3) cases (58 patients). On the basis of this study and literature review, thrombocytosis (>400,000/μL) is a relatively common finding in one third of patients with t(1;3), whereas increase of platelet count by more than 1,000,000/μL is an extremely rare phenomenon, even among patients with t(1;3). To our knowledge, this study is the only documented case that recorded more than 2,000,000/μL of extreme thrombocytosis in a de novo acute myeloid leukemia patient with t(1;3) at initial diagnosis. Because only a few patients with t(1;3) responded to conventional chemotherapy, more aggressive therapy such as stem-cell transplantation should be considered to improve patient survival in t(1;3) cases. |
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Authors:
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Gayoung Lim; Min Jin Kim; Seung Hwan Oh; Sun Young Cho; Hee Joo Lee; Jin-Tae Suh; Juhie Lee; Woo-In Lee; Kyung Sam Cho; Tae Sung Park |
Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Cancer genetics and cytogenetics Volume: 203 ISSN: 1873-4456 ISO Abbreviation: Cancer Genet. Cytogenet. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-15 Completed Date: 2011-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7909240 Medline TA: Cancer Genet Cytogenet Country: United States |
Other Details:
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Languages: eng Pagination: 187-92 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Laboratory Medicine, School of Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-702, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Bone Marrow Cells / cytology Chromosomes, Human, Pair 1* Chromosomes, Human, Pair 3* Female Humans In Situ Hybridization, Fluorescence Karyotyping Leukemia, Myeloid, Acute / genetics* Male Middle Aged Thrombocytosis / genetics* Translocation, Genetic* |
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