Document Detail

Acute myeloid leukemia associated with t(10;17)(p13-15;q12-21) and phagocytic activity by leukemic blasts: a clinical study and review of the literature.
MedLine Citation:
PMID:  20804920     Owner:  NLM     Status:  MEDLINE    
Translocation (10;17)(p13-15;q12-21) in acute leukemia is rarely reported in the literature. Here, we present both a novel t(10;17) case study and a review of relevant literature on t(10;17) in acute leukemia (10 cases). In summary, we came to the following preliminary conclusions: t(10;17) is associated with poorly differentiated acute leukemia subtype [90%; eight cases of acute myeloid leukemia (AML M0, M1) and one case of acute undifferentiated leukemia], phagocytic activity by blasts occurs (30%), and the survival time was short in three of the seven t(10;17) cases for whom follow-up data were available (median, 8 months). More clinical studies concerning the prognosis, treatment response, and survival of patients with t(10;17) are necessary.
Seung Hwan Oh; Tae Sung Park; Sun Young Cho; Min Jin Kim; Jungwon Huh; Bomi Kim; Sae Am Song; Ja Young Lee; Kyung Ran Jun; Jeong Hwan Shin; Hye Ran Kim; Jeong Nyeo Lee
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  202     ISSN:  1873-4456     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-08-31     Completed Date:  2010-09-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  43-6     Citation Subset:  IM    
Copyright Information:
2010 Elsevier Inc. All rights reserved.
Department of Laboratory Medicine, Inje University College of Medicine, Gaegeum-dong, Busanjin-gu, Busan, Korea.
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MeSH Terms
Antigens, CD / metabolism
Antimetabolites, Antineoplastic / therapeutic use
Blast Crisis / pathology
Chromosome Mapping
Chromosomes, Human, Pair 10*
Chromosomes, Human, Pair 17*
Cytarabine / therapeutic use
Daunorubicin / therapeutic use
Leukemia / drug therapy*,  genetics*,  pathology
Magnetic Resonance Imaging
Middle Aged
Peroxidase / metabolism
Phagocytes / pathology
Translocation, Genetic*
Reg. No./Substance:
0/Antigens, CD; 0/Antimetabolites, Antineoplastic; 147-94-4/Cytarabine; 20830-81-3/Daunorubicin; EC

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