| Acute myelogenous leukemia in pregnancy: fetal blood sampling and early effects of chemotherapy. | |
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MedLine Citation:
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PMID: 7909767 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This report documents the acute toxicity of anti-leukemic chemotherapy on the fetus in utero by umbilical blood sampling. A patient with acute myelocytic leukemia diagnosed at the 23rd week of gestation received combination chemotherapy, and carried the pregnancy to successful delivery at the 34th week. During the course of pregnancy, the fetal condition was evaluated by serial real time sonograms and umbilical blood sampling through cordocentesis. Fetal hematopoiesis was preserved against maternal chemotherapeutic agents, and no developmental abnormalities were observed. This is the first attempt to evaluate the acute effects of chemotherapeutic agents on the fetus in utero by real time umbilical cord sampling. |
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Authors:
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S Morishita; A Imai; I Kawabata; T Tamaya |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics Volume: 44 ISSN: 0020-7292 ISO Abbreviation: Int J Gynaecol Obstet Publication Date: 1994 Mar |
Date Detail:
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Created Date: 1994-06-09 Completed Date: 1994-06-09 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0210174 Medline TA: Int J Gynaecol Obstet Country: IRELAND |
Other Details:
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Languages: eng Pagination: 273-7 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Gifu University School of Medicine Tsukasamachi, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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6-Mercaptopurine
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administration & dosage Adult Antineoplastic Combined Chemotherapy Protocols / adverse effects, therapeutic use* Cytarabine / administration & dosage, analogs & derivatives Daunorubicin / administration & dosage Female Fetal Blood / cytology* Fetal Growth Retardation / chemically induced*, diagnosis Fetus / drug effects* Humans Infant, Newborn Leukemia, Myeloid, Acute / drug therapy* Prednisolone / administration & dosage Pregnancy Pregnancy Complications, Neoplastic / drug therapy* Ultrasonography, Prenatal |
| Chemical | |
Reg. No./Substance:
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147-94-4/Cytarabine; 20830-81-3/Daunorubicin; 50-24-8/Prednisolone; 50-44-2/6-Mercaptopurine; 55726-47-1/enocitabine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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