Document Detail

Acute myeloblastic leukemia.
MedLine Citation:
PMID:  21431629     Owner:  NLM     Status:  In-Process    
Myelodysplastic syndromes (MDS) are a group of clonal cell disorders characterized by maturation defects, resulting in ineffective hematopoiesis. They often transform to acute myeloblastic leukemia (AML), which is difficult to treat and carries a dismal prognosis. Azacitidine is a hypomethylating agent approved for the treatment of patients with MDS, including AML with 20% to 30% bone marrow blasts, according to World Health Organization classification. The three patient cases presented in this paper exemplify the spectrum of antitumor activity and toxicity of azactidine in patients where MDS transformed to AML.
Carmen Avellaneda Molina; Maria José Requena Rodríguez; Nieves Somolinos de Marcos; Patricia Font
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-03-09
Journal Detail:
Title:  Advances in therapy     Volume:  28 Suppl 3     ISSN:  1865-8652     ISO Abbreviation:  Adv Ther     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8611864     Medline TA:  Adv Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  10-6     Citation Subset:  T    
Department of Hematology, Hospital Universitario San Agustín, Linares, Jaén, Spain.
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