Document Detail


Acute myeloblastic leukemia associated with hyperleukocytosis and diabetes insipidus.
MedLine Citation:
PMID:  9711928     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two cases with acute myeloblastic leukemia (AML M4-FAB) associated with diabetes insipidus (DI) are presented here. Both patients presented with hyperleucocytosis. One had a white blood cell count (WBC) of 150 x 10(9)/L and the second patient had 200 x 10(9)/L. One of these patients was a 40 year-old male and MRI of the hypophysis showed an infindibuler mass. This patient did not respond to remission induction chemotherapy and reinduction chemotherapy was given. The other patient was a 16-year-old male with a normal CT scan of the head. Both patients had DI with typical clinical and laboratory findings. The first patient died early on during reinduction chemotherapy and the second patient died of intracranial bleeding before induction chemotherapy was given. These findings are consistent with the data in the literature suggesting that the prognosis of AML associated with DI is poor and that these cases generally present with hyperleucocytosis.
Authors:
I Dilek; A Uysal; T Demirer; H Koç; M Ozcan; H Keleş; N Numaoğlu; C Ustün; E Ciftçi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  30     ISSN:  1042-8194     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-10-22     Completed Date:  1998-10-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  657-60     Citation Subset:  IM    
Affiliation:
Department of Hematology-Oncology, Ankara University Medical School, Ibn-i Sina Hospital, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Diabetes Insipidus / complications*,  radiography
Humans
Leukemia, Myeloid, Acute / complications*,  radiography
Leukocytosis / complications*,  radiography
Male
Pituitary Gland / radiography
Tomography, X-Ray Computed

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