Document Detail

Acute multifocal skin necrosis: synergism between invasive streptococcal infection and cocaine-induced tissue ischaemia?
MedLine Citation:
PMID:  8800309     Owner:  NLM     Status:  MEDLINE    
A 30-year-old pregnant woman with full thickness skin necrosis following parenteral abuse of cocaine and heroine is described. Three lesions occurred simultaneously on the trunk and right knee subsequent to an abscess on the left thigh from which S. pyogenes group A and S. aureus were isolated. Histology revealed necrotic subcutaneous tissue with obliterated vessels and a mixed inflammatory infiltrate. The sequence of events suggests a synergism between the effects of bacterial proteases and cocaine-induced impairment of soft tissue perfusion. In the present case, this synergism may have been further enhanced by decreased cocaine tolerance during pregnancy.
P H Hoeger; G Haupt; E Hoelzle
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  76     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  1996 May 
Date Detail:
Created Date:  1997-04-08     Completed Date:  1997-04-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  239-41     Citation Subset:  IM    
Department of Dermatology, University of Hamburg, Germany.
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MeSH Terms
Heroin Dependence / complications
Pregnancy Complications*
Pregnancy Complications, Infectious / pathology
Skin / pathology*
Skin Diseases, Bacterial / complications,  pathology*
Streptococcal Infections / complications,  pathology*
Substance Abuse, Intravenous / complications*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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