Document Detail

Acute monocytic leukemia: a myeloid leukemia subset that may be sensitive to methotrexate.
MedLine Citation:
PMID:  7532768     Owner:  NLM     Status:  MEDLINE    
Impaired polyglutamylation of methotrexate (MTX) and thus poor retention is believed to be the basis of intrinsic resistance in blasts from patients with acute myeloid leukemia (AML) to MTX. We studied additional samples from patients with this disease, and confirmed that polyglutamylation of MTX was poor in ANLL blast cells. However, in one subset of ANLL, acute monocytic leukemia, (M5) leukemia blasts were found to be capable of accumulating and forming long-chain MTX polyglutamates. An acute monocytic leukemia cell line, THP-1 also was found to accumulate high levels of MTX polyglutamates and was relatively sensitive to MTX, strengthening the concept that M5 blasts may be sensitive to this drug. MTX may be an overlooked drug for the treatment of acute monocytic leukemia.
E Göker; A Kheradpour; M Waltham; D Banerjee; W P Tong; Y Elisseyeff; J R Bertino
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Leukemia     Volume:  9     ISSN:  0887-6924     ISO Abbreviation:  Leukemia     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-03-30     Completed Date:  1995-03-30     Revised Date:  2013-03-04    
Medline Journal Info:
Nlm Unique ID:  8704895     Medline TA:  Leukemia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  274-6     Citation Subset:  IM    
Program of Molecular Pharmacology and Therapeutics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
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MeSH Terms
Biological Transport
Drug Resistance
Leukemia, Monocytic, Acute / drug therapy*,  pathology
Leukemia, Myeloid, Acute / classification,  metabolism,  pathology
Methotrexate / analogs & derivatives*,  metabolism,  pharmacokinetics,  pharmacology*
Middle Aged
Neoplastic Stem Cells / drug effects*,  metabolism
Polyglutamic Acid / analogs & derivatives*,  metabolism
Tumor Cells, Cultured / drug effects
Reg. No./Substance:
25513-46-6/Polyglutamic Acid; 59-05-2/Methotrexate; 82334-40-5/methotrexate polyglutamate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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