Document Detail

Acute monoarthritis associated with lipid liquid crystals.
MedLine Citation:
PMID:  2992399     Owner:  NLM     Status:  MEDLINE    
We describe three women with unexplained acute monoarthritis and birefringent lipid spherules or lipid liquid crystals in their synovial fluid. Synovial fluid aspirated within 24 hours of onset showed leucocyte counts ranging from 10 X 10(9) to 46 X 10(9)/1 with 91-95% polymorphonuclear cells. Numerous positively birefringent 2-6 micron microspherules were seen inside and outside polymorphonuclear cells. These were dissolved in alcohol-ether but were not digested by uricase. Other non-birefringent globules of similar size that stained with Sudan black B were also seen. Transmission electron microscopy identified osmiophilic homogeneous or multilamellated material in phagocytic vacuoles. Serum lipids, lipase, and repeated joint radiographs were normal. Arthritis subsided completely after treatment with colchicine in one patient and nonsteroidal anti-inflammatory agents in two. Thus birefringent microspherules can be found in association with acute, otherwise unexplained, arthritis. It seems possible that certain lipid liquid crystals may induce synovial inflammation similar to inflammation seen in other crystal induced arthritides.
A J Reginato; H R Schumacher; D A Allan; J L Rabinowitz
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  44     ISSN:  0003-4967     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  1985 Aug 
Date Detail:
Created Date:  1985-09-19     Completed Date:  1985-09-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  537-43     Citation Subset:  IM    
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MeSH Terms
Arthritis / metabolism*,  pathology
Inclusion Bodies / ultrastructure
Lipids / analysis*
Microscopy, Electron
Middle Aged
Phospholipids / analysis
Synovial Fluid / analysis*
Reg. No./Substance:
0/Lipids; 0/Phospholipids

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