Document Detail

Acute methyl iodide exposure with delayed neuropsychiatric sequelae: report of a case.
MedLine Citation:
PMID:  15898088     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Methyl iodide is a monohalomethane used as an analytic and organic chemistry reagent, as a methylating agent in organic chemical synthesis, and as a fumigant. In an acute exposure, methyl iodide is a pulmonary and dermal irritant. Chronic neurotoxicity has been reported in survivors of acute exposure. METHODS: A review of the 11 case reports of methyl iodide poisoning in the medical literature of the 20th century found that six of the patients experienced a chronic neurological syndrome characterized primarily by delayed psychiatric, behavioral, and cognitive sequelae. RESULTS: The case patient experienced a massive exposure to methyl iodide with resulting life-threatening burns. During convalescence, various cognitive and behavioral deficits became apparent. The results of a comprehensive evaluation at our occupational toxicology clinic, which included sequential neuropsychometric testing, are described. CONCLUSION: The findings in the case patient may advance our understanding of the mechanisms and clinical manifestations of chronic neurotoxicity after exposure to methyl iodide.
Michael D Schwartz; Andrew O Obamwonyi; Jerry D Thomas; Joel F Moorhead; Brent W Morgan
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of industrial medicine     Volume:  47     ISSN:  0271-3586     ISO Abbreviation:  Am. J. Ind. Med.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-23     Completed Date:  2005-10-07     Revised Date:  2006-02-27    
Medline Journal Info:
Nlm Unique ID:  8101110     Medline TA:  Am J Ind Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  550-6     Citation Subset:  IM    
Department of Emergency Medicine, Georgia Poison Center/Emory University, Atlanta, Georgia 30333, USA.
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MeSH Terms
Acute Disease
Hydrocarbons, Iodinated / toxicity*
Middle Aged
Neurotoxicity Syndromes / etiology*
Occupational Exposure / adverse effects*
Time Factors
Reg. No./Substance:
0/Hydrocarbons, Iodinated; 74-88-4/methyl iodide

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