| Acute megakaryocytic leukemia (AMKL,FAB;M7) with Beckwith-Wiedemann syndrome. | |
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MedLine Citation:
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PMID: 20589645 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Beckwith-Wiedemann syndrome (BWS) is characterized by an accumulation of multiple congenital anomalies. Although patients with BWS are known to have a higher incidence of embryonal tumors, there has been no reports associated with acute leukemia. This report describes the case of a patient with BWS who developed Acute Megakaryocytic Leukemia (AMKL,FAB;M7). Because most patients with BWS present gigantism, the therapy-related toxicity of chemotherapy can be a very serious problem. This patient exhibited no therapy-related toxicity after chemotherapy, suggesting that acute leukemia with BWS may not require a reduction in dosage. |
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Authors:
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Shohei Yamamoto; Daisuke Toyama; Hitomi Yatsuki; Ken Higashimoto; Hidenobu Soejima; Keiichi Isoyama |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pediatric blood & cancer Volume: 55 ISSN: 1545-5017 ISO Abbreviation: Pediatr Blood Cancer Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-08-31 Completed Date: 2010-09-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101186624 Medline TA: Pediatr Blood Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 733-5 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Wiley-Liss, Inc. |
Affiliation:
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Division of Pediatrics, Department of Showa University Fujigaoka Hospital, Aoba-ku, Yokohama, Kanagawa, Japan. shohei-y@showa-university-fujigaoka.gr.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Beckwith-Wiedemann Syndrome
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complications* Humans Infant Leukemia, Megakaryoblastic, Acute / etiology* Male |
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