| Acute megakaryoblastic leukemia in an infant with a novel t(1;9)(p32;q34). | |
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MedLine Citation:
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PMID: 11104035 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a case of a 14-month-old girl with acute megakaryoblastic leukemia (AMKL). May-Giemsa staining of the bone marrow cells revealed the proliferation of two distinct types of blasts. One type of blasts had cytoplasmic blebs, and the other showed a lymphoblastic morphology without blebs. Both types of blasts were negative for peroxidase and esterase reactions. Electron microscopic platelet peroxidase (PPO) reaction also revealed the presence of two types of blasts. One had irregular-shaped nuclei and positive PPO reaction in the nuclear envelope and rough endoplasmic reticulum but not in the Golgi apparatus. These types of blasts were considered to be megakaryoblasts. The other had an immature phenotype with round nuclei and positive PPO reaction in the nuclear envelope, rough endoplasmic reticulum, and the Golgi apparatus. The origin of this type of blasts could not be defined by their morphology. Surface marker analysis indicated that most of the leukemic cells expressed platelet markers, gpIIb, gpIIb/IIIa, gpIX, and gpIbalpha. Karyotypic analysis of the bone marrow cells of this unique subset of AMKL demonstrated a novel translocation, t(1;9)(p32;q34). |
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Authors:
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D Hasegawa; K Sano; Y Kosaka; A Hayakawa; R Kawagoe; K Kawasaki; H Nakamura |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Cancer genetics and cytogenetics Volume: 122 ISSN: 0165-4608 ISO Abbreviation: Cancer Genet. Cytogenet. Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2000-12-04 Completed Date: 2000-12-22 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7909240 Medline TA: Cancer Genet Cytogenet Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 59-62 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Kobe University School of Medicine, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Platelets
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enzymology* Bone Marrow / enzymology, ultrastructure Chromosomes, Human, Pair 1* Chromosomes, Human, Pair 9* Female Flow Cytometry Humans Infant Karyotyping Leukemia, Megakaryoblastic, Acute / genetics* Microscopy, Electron Peroxidases / metabolism Translocation, Genetic* |
| Chemical | |
Reg. No./Substance:
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EC 1.11.1.-/Peroxidases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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