| Acute megakaryoblastic leukemia following transient myeloproliferative disorder in a patient without Down syndrome. | |
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MedLine Citation:
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PMID: 7977305 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Transient myeloproliferative disorder (TMD) and subsequent acute myeloid leukemia (AML) occur with increased frequency in infants and children with Down syndrome. TMD can also occur in phenotypically normal newborns. We describe the second case of a non-Down syndrome child with TMD who subsequently developed AML. Trisomy 21 karyotypic was restricted to hematopoietic cells in the blood and bone marrow. No other karyotypic abnormalities were found. Leukemic blasts showed megakaryoblastic features with immunophenotyping. This case shows that TMD in a child without Down syndrome may not be entirely benign. Close follow-up is warranted. |
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Authors:
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M D Brissette; B J Duval-Arnould; B G Gordon; J D Cotelingam |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: American journal of hematology Volume: 47 ISSN: 0361-8609 ISO Abbreviation: Am. J. Hematol. Publication Date: 1994 Dec |
Date Detail:
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Created Date: 1994-12-27 Completed Date: 1994-12-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7610369 Medline TA: Am J Hematol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 316-9 Citation Subset: IM |
Affiliation:
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Department of Pathology, Madigan Army Medical Center, Tacoma, Washington. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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DNA, Neoplasm
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genetics Down Syndrome Humans Infant Infant, Newborn Leukemia, Megakaryoblastic, Acute / genetics* Male Myeloproliferative Disorders / complications*, congenital |
| Chemical | |
Reg. No./Substance:
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0/DNA, Neoplasm |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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