Document Detail


Acute mechanical effects of elastase on the infrarenal mouse aorta: implications for models of aneurysms.
MedLine Citation:
PMID:  22236532     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intraluminal exposure of the infrarenal aorta to porcine pancreatic elastase represents one of the most commonly used experimental models of the development and progression of abdominal aortic aneurysms. Morphological and histological effects of elastase on the aortic wall have been well documented in multiple rodent models, but there has been little attention to the associated effects on mechanical properties. In this paper, we present the first biaxial mechanical data on, and associated nonlinear constitutive descriptors of, the effects of elastase on the infrarenal aorta in mice. Quantification of the dramatic, acute effects of elastase on wall behavior in vitro is an essential first step toward understanding the growth and remodeling of aneurysms in vivo, which depends on both the initial changes in the mechanics and the subsequent inflammation-mediated turnover of cells and extracellular matrix that contributes to the evolving mechanics.
Authors:
M J Collins; J F Eberth; E Wilson; J D Humphrey
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-01-10
Journal Detail:
Title:  Journal of biomechanics     Volume:  45     ISSN:  1873-2380     ISO Abbreviation:  J Biomech     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-13     Completed Date:  2012-06-08     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  0157375     Medline TA:  J Biomech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  660-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta, Abdominal / metabolism,  pathology,  physiopathology*
Aortic Aneurysm, Abdominal / chemically induced,  metabolism,  pathology,  physiopathology*
Disease Models, Animal
Extracellular Matrix / metabolism
Male
Mice
Models, Cardiovascular*
Pancreatic Elastase / adverse effects*,  pharmacology
Swine
Grant Support
ID/Acronym/Agency:
R01 HL105297/HL/NHLBI NIH HHS; R01 HL105297/HL/NHLBI NIH HHS; R01 HL105297-02/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
EC 3.4.21.36/Pancreatic Elastase
Comments/Corrections

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