| Acute massive gentamicin intoxication in a patient with end-stage renal disease. | |
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MedLine Citation:
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PMID: 9158219 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 65-year-old man with end-stage renal disease on continuous ambulatory peritoneal dialysis accidentally received an acute massive overdose of gentamicin as a treatment of peritonitis. The patient developed acute vestibular dysfunction and hearing loss following the overdose. His serum gentamicin had reached the extremely toxic level of 220 microg/mL. To remove the gentamicin, the patient received hemodialysis and hemoperfusion immediately. This was followed by two more courses of hemodialysis during the following 2 days. The gentamicin level was brought down to 10 microg/mL after the third hemodialysis. Moderate and persistent high-frequency hearing loss was documented with serial audiograms. The patient made a gradual but incomplete recovery from the vestibular dysfunction. The complications of gentamicin toxicity and its management are discussed with respect to our patient. |
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Authors:
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C M Lu; S H James; Y H Lien |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: American journal of kidney diseases : the official journal of the National Kidney Foundation Volume: 28 ISSN: 0272-6386 ISO Abbreviation: Am. J. Kidney Dis. Publication Date: 1996 Nov |
Date Detail:
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Created Date: 1997-06-09 Completed Date: 1997-06-09 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8110075 Medline TA: Am J Kidney Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 767-71 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Arizona Health Sciences Center, Tucson 85724, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anti-Bacterial Agents / administration & dosage, adverse effects*, blood Gentamicins / administration & dosage, adverse effects*, blood Hearing Loss, High-Frequency / chemically induced* Hemoperfusion Humans Kidney Failure, Chronic / therapy* Male Overdose Peritoneal Dialysis, Continuous Ambulatory* / adverse effects Peritonitis / drug therapy Renal Dialysis Vestibular Diseases / chemically induced* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Gentamicins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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