Document Detail

Acute lymphoblastic leukemic transformation in a patient with chronic idiopathic myelofibrosis and paroxysmal nocturnal hemoglobinuria: a case report and review of the literature.
MedLine Citation:
PMID:  15628917     Owner:  NLM     Status:  MEDLINE    
Leukemic transformation of chronic idiopathic myelofibrosis (CIMF) to acute lymphoblastic leukemia (ALL) is rare. We report a case of a patient with CIMF who developed paroxysmal nocturnal hemoglobinuria (PNH) 2 years after initial presentation. His disease eventually transformed to ALL of precursor B-cell type. In that CIMF and PNH are clonal stem cell disorders with different pathogeneses, there may be an association between them. However, leukemic transformation is a rare sequel of both disorders. Coexistence of CIMF and PNH and subsequent transformation to ALL have, to our knowledge, never been previously reported in the world literature. The simultaneous presentation of CIMF and PNH, complicated by the rare sequela of leukemic transformation, raises important issues with regard to diagnosis and treatment.
Saad Paul Shaheen; Sameer S Talwalkar; Ruth Simons; Lung Yam
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  129     ISSN:  1543-2165     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-04     Completed Date:  2005-06-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  96-9     Citation Subset:  AIM; IM    
Department of Pathology, University of Louisville, KY, USA. <>
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MeSH Terms
Chronic Disease
Hemoglobinuria, Paroxysmal / etiology*
Middle Aged
Precursor Cell Lymphoblastic Leukemia-Lymphoma / etiology*
Primary Myelofibrosis / complications*

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