| Acute lymphoblastic leukemia with azurophilic granules that contain ultrastructural myeloperoxidase activity. | |
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MedLine Citation:
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PMID: 1707229 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We present a case of acute lymphoblastic leukemia (ALL) in which the leukemic cells had cytoplasmic azurophilic granules. Surface marker studies revealed that the leukemic cells expressed CD10 (CALLA), CD19, CD20, and HLA-DR antigens. Cytochemical studies by light microscopy revealed that the blasts were negative for myeloperoxidase, PAS staining, and double esterase staining, supporting the diagnosis of ALL. However, an ultrastructural study demonstrated that some of the cytoplasmic granules were myeloperoxidase (MPO) positive. Our findings suggested that leukemic transformation in this case may have taken place at a stage ontogenetically close to the pluripotent stem cell. Furthermore, the present case indicates the existence of a new form of ALL is characterized by MPO-positive granules detectable by ultracytochemistry and lymphoid-associated surface markers. |
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Authors:
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T Tauchi; K Ohyashiki; J H Ohyashiki; M Saito; S Nakazawa; Y Enomoto; Y Hosoda; K Toyama |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: American journal of hematology Volume: 36 ISSN: 0361-8609 ISO Abbreviation: Am. J. Hematol. Publication Date: 1991 Apr |
Date Detail:
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Created Date: 1991-05-06 Completed Date: 1991-05-06 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7610369 Medline TA: Am J Hematol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 288-90 Citation Subset: IM |
Affiliation:
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First Department of Internal Medicine, Tokyo Medical College, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD19 Antigens, CD20 Antigens, Differentiation / metabolism Antigens, Differentiation, B-Lymphocyte / metabolism Antigens, Neoplasm / metabolism Azure Stains / diagnostic use Cytoplasmic Granules / enzymology*, ultrastructure Female Genotype HLA-DR Antigens / metabolism Histocytochemistry / methods Humans Lymphocyte Activation Microscopy, Electron / methods Middle Aged Neprilysin Peroxidase / metabolism* Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics, metabolism, pathology* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD19; 0/Antigens, CD20; 0/Antigens, Differentiation; 0/Antigens, Differentiation, B-Lymphocyte; 0/Antigens, Neoplasm; 0/Azure Stains; 0/HLA-DR Antigens; EC 1.11.1.7/Peroxidase; EC 3.4.24.11/Neprilysin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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