Document Detail


Acute lymphoblastic leukemia occurring as a second malignant neoplasm in childhood: report of three cases and review of the literature.
MedLine Citation:
PMID:  1309379     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The long-term effects of childhood cancer and its therapy are a problem of increasing concern. One of the most important of these late effects is the development of second malignant neoplasms (SMNs), which occur in approximately 8% of children within 20 years of diagnosis of a malignancy. These secondary cancers may result (individually or in combination) from increased genetic susceptibility, the mutagenic effects of chemotherapy and/or radiation therapy, or chance. Whereas the development of acute nonlymphocytic leukemia (ANLL) as an SMN is a well-recognized phenomenon, acute lymphoblastic leukemia (ALL) has been infrequently described as an SMN in either adults or children. PATIENTS AND METHODS: We report three patients treated at our institution in whom ALL developed as an SMN after treatment for neuroblastoma, Wilms' tumor, and Hodgkin's disease. These cases prompted us to review the published literature for cases of secondary ALL in childhood. Patients whose initial malignancy was diagnosed at age less than 16 years were classified as pediatric patients. SMNs were defined as cancers of clearly distinct histologic type occurring 6 or more months after diagnosis of the first malignant neoplasm. RESULTS: Including the three index cases, a total of 18 children with secondary ALL are reviewed, and the clinical features are discussed and compared with those of secondary ANLL. CONCLUSIONS: This review summarizes the published case histories of secondary ALL. The data suggest that ALL represents approximately 5% to 10% of the cases of acute leukemia that arise as SMNs in both adults and children.
Authors:
S P Hunger; J Sklar; M P Link
Related Documents :
2915919 - Are most secondary acute lymphoblastic leukemias mixed acute leukemias?
7050389 - Monoclonal immunoglobulin of cll lymphocytes detected by radioimmunofixation with 125i-...
12694439 - Gingival lesions in a patient with chronic oral graft-versus-host disease: a case report.
1638489 - Monosomy 21 in two patients with acute nonlymphocytic leukemia.
20147849 - Free air intraperitoneally during chemotherapy for acute lymphoblastic leukemia: consid...
6839299 - Paroxysmal nocturnal hemoglobinuria and acute non-lymphocytic leukemia. a report of thr...
16402459 - The acute surgical abdomen following kyphoscoliosis corrective surgery.
8683269 - Aplasia cutis congenita. case report.
17268129 - Gasperini syndrome, a report of two cases.
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of clinical oncology : official journal of the American Society of Clinical Oncology     Volume:  10     ISSN:  0732-183X     ISO Abbreviation:  J. Clin. Oncol.     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-01-27     Completed Date:  1992-01-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8309333     Medline TA:  J Clin Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  156-63     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Stanford University School of Medicine, CA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Child
Child, Preschool
Female
Hodgkin Disease
Humans
Male
Neoplasms, Second Primary* / genetics
Neuroblastoma
Precursor Cell Lymphoblastic Leukemia-Lymphoma* / genetics
Wilms Tumor
Grant Support
ID/Acronym/Agency:
CA 34233/CA/NCI NIH HHS
Comments/Corrections
Comment In:
J Clin Oncol. 1992 May;10(5):866   [PMID:  1569459 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Gp-regulated phosphoinositide hydrolysis in turkey and human erythrocytes exposed to fluoride ion: r...
Next Document:  A phase II study of CPT-11, a new derivative of camptothecin, for previously untreated non-small-cel...