Document Detail


Acute lymphoblastic leukemia in a child with hemoglobins S and Q-Iran.
MedLine Citation:
PMID:  2288017     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 13-year-old girl with acute lymphoblastic leukemia is presented. The peripheral smear showed, in addition to lymphoblasts, marked anisocytosis, poikilocytosis, and polychromasia. In vitro sickling test was positive. Hemoglobin electrophoresis at pH 9.0 on starch gel revealed the presence of hemoglobin A, hemoglobin S, and a band with a mobility of hemoglobin A2. Structural analysis revealed the presence of hemoglobin S and an alpha-chain variant, hemoglobin Q-Iran. The patient attained remission with the initial therapy administered but a relapse occurred five months later. Our study indicates the need for detailed investigation of leukemia patients in which abnormal hemoglobins are prevalent.
Authors:
A Gürgey; S Ozsoylu; G Hiçsönmez; G Irken; C Altay
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Turkish journal of pediatrics     Volume:  32     ISSN:  0041-4301     ISO Abbreviation:  Turk. J. Pediatr.     Publication Date:    1990 Jan-Mar
Date Detail:
Created Date:  1991-03-27     Completed Date:  1991-03-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0417505     Medline TA:  Turk J Pediatr     Country:  TURKEY    
Other Details:
Languages:  eng     Pagination:  39-41     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara.
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MeSH Terms
Descriptor/Qualifier:
Child
Electrophoresis
Female
Hemoglobin A / analysis
Hemoglobin A2 / analysis
Hemoglobin, Sickle* / analysis
Hemoglobinopathies / complications*
Hemoglobins, Abnormal* / analysis
Humans
Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications*
Turkey
Chemical
Reg. No./Substance:
0/Hemoglobin, Sickle; 0/Hemoglobins, Abnormal; 39444-51-4/hemoglobin Q Iran; 9034-51-9/Hemoglobin A; 9034-53-1/Hemoglobin A2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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