Document Detail


Acute lymphoblastic leukemia. Survey of immunophenotype, French-American-British classification, frequency of myeloid antigen expression, and karyotypic abnormalities in 210 pediatric and adult cases.
MedLine Citation:
PMID:  10191766     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Immunophenotypic studies are essential to distinguish acute lymphoblastic leukemia (ALL) from minimally differentiated acute myeloid leukemia (AMLM0) and to classify ALL into immunologic subtypes. Frequently, immunophenotyping identifies myeloid antigen expression in ALL, causing a potential diagnostic problem. To evaluate the immunophenotype of ALL, we studied 210 cases of pediatric and adult ALL by flow cytometry and compared the results with the French-American-British (FAB) Cooperative Group classification and the karyotypic findings. Myeloid-associated antigens were expressed in 78 (45.6%) of precursor B-cell ALL cases. Pediatric precursor B ALLs had a higher frequency of myeloid antigen expression than did adult cases. All mature B-cell ALL cases were negative for TdT and myeloid antigens. Myeloid antigen expression was less frequent in T-cell ALL cases compared with precursor B-cell ALL cases. Of the 192 cases submitted for cytogenetic analysis, 147 were abnormal. The most common chromosomal translocation was the Philadelphia chromosome, which was more likely to have L2 blast morphology and a precursor B immunophenotype. Myeloid antigen expression was present in 70.8% of Ph-positive cases (P = .008). Chromosome rearrangements involving 11q23 also showed an increased frequency of myeloid antigen expression. Chromosome translocations involving regions of T-cell receptor genes were present in 24% of T-cell ALL cases. A high percentage of ALL cases, however, had various other cytogenetic abnormalities, many of which involved less well-studied chromosomal regions.
Authors:
H S Khalidi; K L Chang; L J Medeiros; R K Brynes; M L Slovak; J L Murata-Collins; D A Arber
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  111     ISSN:  0002-9173     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-04-16     Completed Date:  1999-04-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  467-76     Citation Subset:  AIM; IM    
Affiliation:
Division of Pathology, City of Hope National Medical Center, Duarte, California 91010, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Antigens, Differentiation, Myelomonocytic / analysis*
Child
Child, Preschool
Chromosome Aberrations*
Female
France
Great Britain
Humans
Immunophenotyping*
Infant
Karyotyping*
Male
Middle Aged
Precursor Cell Lymphoblastic Leukemia-Lymphoma* / classification,  genetics,  immunology
Recurrence
United States
Grant Support
ID/Acronym/Agency:
CA 30206/CA/NCI NIH HHS; CA-33572/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, Differentiation, Myelomonocytic

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