Document Detail

Acute lung injury during antithymocyte globulin therapy for aplastic anemia.
MedLine Citation:
PMID:  19399304     Owner:  NLM     Status:  MEDLINE    
The case of a 33-year-old man with aplastic anemia who experienced recurrent episodes of hypoxemia and pulmonary infiltrates during infusions of antithymocyte globulin (ATG) is described. With the use of high-dose corticosteroids, the patient's original episodes resolved, and were subsequently prevented before additional administrations of ATG. Rare reports of an association between ATG and acute lung injury are found in the literature, but this is the first report of successful steroid-supported re-exposure. Although the mechanism of ATG-related acute lung injury remains uncertain, it may be parallel to the mechanism of transfusion-related acute lung injury because the pathogenesis of the latter relies, in part, on antileukocyte antibodies. ATG-related toxicity should be included in the differential diagnosis of new, infusion-associated pulmonary infiltrates, and corticosteroids may be a useful therapeutic consideration in the management.
Ewan Christopher Goligher; Christine Cserti-Gazdewich; Meyer Balter; Vikas Gupta; Joseph E Brandwein
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Canadian respiratory journal : journal of the Canadian Thoracic Society     Volume:  16     ISSN:  1916-7245     ISO Abbreviation:  Can. Respir. J.     Publication Date:    2009 Mar-Apr
Date Detail:
Created Date:  2009-04-28     Completed Date:  2010-06-10     Revised Date:  2010-09-27    
Medline Journal Info:
Nlm Unique ID:  9433332     Medline TA:  Can Respir J     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  e3-5     Citation Subset:  IM    
Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
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MeSH Terms
Acute Lung Injury / chemically induced*,  diagnosis,  drug therapy
Adrenal Cortex Hormones / therapeutic use
Anemia, Aplastic / drug therapy*
Antilymphocyte Serum / adverse effects*,  therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Antilymphocyte Serum

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