| Acute and long term effects of grape and pomegranate juice consumption on endothelial dysfunction in pediatric metabolic syndrome. | |
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MedLine Citation:
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PMID: 22091240 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: This study aimed to determine the short- and long-term effects of consumption of grape and pomegranate juices on markers of endothelial function and inflammation in adolescents with metabolic syndrome (MetS). METHODS: In a non-pharmacologic randomized controlled trial, 30 individuals were randomly assigned to two groups of drinking natural grape or pomegranate juice for 1 month. Measurements of inflammatory factors [Hs-CRP, sE-selectin, sICAM-1, sVCAM, and interleukin 6 (IL-6)] and flow-mediated dilation (FMD) were made at baseline, 4 hours after first juice consumption and after one month of juice consumption. RESULTS: The percent changes of FMD were significant in both groups in the short- and long-term. Hs-CRP had a nonsignificant decrease. sE selectin had a significant decrease after 4 hours in total and in the pomegranate juice group, followed by a significant decrease after 1 month in both groups. After 4 hours, sICAM-1 significantly decreased in the pomegranate juice group, and after 1 month it decreased in total and pomegranate juice group. Interleulkin-6 (IL-6) had a significant constant decrease at 4-hour and 1-month measurements after drinking pomegranate juice, and in both groups after 1 month. Significant negative correlations of changes in sICAM-1 and sE-selectin with changes in FMD were found in both periods of follow-up; and at 1 month for IL-6. CONCLUSIONS: Decline in inflammation was associated with improvement in FMD without changes in conventional risk factors. Daily consumption of natural antioxidants may improve endothelial function in adolescents with MetS. |
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Authors:
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Roya Kelishadi; Samuel S Gidding; Mohammad Hashemi; Mahin Hashemipour; Afshin Zakerameli; Parinaz Poursafa |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences Volume: 16 ISSN: 1735-7136 ISO Abbreviation: J Res Med Sci Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-11-17 Completed Date: 2011-11-23 Revised Date: 2013-05-29 |
Medline Journal Info:
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Nlm Unique ID: 101235599 Medline TA: J Res Med Sci Country: Iran |
Other Details:
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Languages: eng Pagination: 245-53 Citation Subset: - |
Affiliation:
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Professor of Pediatrics, Department of Pediatrics, Child Health Promotion Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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