Document Detail

Acute and long-term effects of MDMA on cerebral dopamine biochemistry and function.
MedLine Citation:
PMID:  15083264     Owner:  NLM     Status:  MEDLINE    
RATIONALE AND OBJECTIVES: The majority of experimental and clinical studies on the pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) tend to focus on its action on 5-HT biochemistry and function. However, there is considerable evidence for MDMA having marked acute effects on dopamine release. Furthermore, while MDMA produces long-term effects on 5-HT neurones in most species examined, in mice its long-term effects appear to be restricted to the dopamine system. The objective of this review is to examine the actions of MDMA on dopamine biochemistry and function in mice, rats, guinea pigs, monkeys and humans.
RESULTS AND DISCUSSION: MDMA appears to produce a major release of dopamine from its nerve endings in all species investigated. This release plays a significant role in the expression of many of the behaviours that occur, including behavioural changes, alterations of the mental state in humans and the potentially life-threatening hyperthermia that can occur. While MDMA appears to be a selective 5-HT neurotoxin in most species examined (rats, guinea pigs and primates), it is a selective dopamine neurotoxin in mice. Selectivity may be a consequence of what neurotoxic metabolites are produced (which may depend on dosing schedules), their selectivity for monoamine nerve endings, or the endogenous free radical trapping ability of specific nerve endings, or both. We suggest more focus be made on the actions of MDMA on dopamine neurochemistry and function to provide a better understanding of the acute and long-term consequences of using this popular recreational drug.
M Isabel Colado; Esther O'Shea; A Richard Green
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2004-04-09
Journal Detail:
Title:  Psychopharmacology     Volume:  173     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-05-12     Completed Date:  2004-11-22     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  249-63     Citation Subset:  IM    
Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain.
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MeSH Terms
Brain / drug effects*,  metabolism
Dopamine / metabolism,  physiology*
Hallucinogens / metabolism,  pharmacology*,  toxicity
N-Methyl-3,4-methylenedioxyamphetamine / metabolism,  pharmacology*,  toxicity
Species Specificity
Reg. No./Substance:
0/Hallucinogens; 42542-10-9/N-Methyl-3,4-methylenedioxyamphetamine

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