Document Detail

Acute liver failure in children: 20-year experience.
MedLine Citation:
PMID:  22706740     Owner:  NLM     Status:  In-Data-Review    
Background/aims: We aimed to determine the causes, demographic findings, clinical status, outcomes, and prognostic risk factors of patients with acute liver failure admitted to Hacettepe University Children's Hospital between October 1987 - October 2006. Met- hods: This retrospective case study included 74 patients with acute liver failure according to the Pediatric Acute Liver Failure Study Group definition. Results: The etiology of acute liver failure was metabolic in 26 (35.1%) and infectious in 21 (28.4%) patients. Six- teen (21.6%) patients had indeterminate causes. Wilson's disease (16/26 patients, 61.5%) was the most frequent metabolic disease, while hepatitis A (14/21 patients, 66.7%) was the most frequent infectious agent. Neurologic functions were normal in 21 (28.4%) patients. Forty-nine (66.2%) patients died and 24 (32.4%) recovered. Two patients underwent liver transplantation. The mortality rate was 82.9% for patients who were not transplanted but fulfilled King's College Hospital criteria and 45.4% for patients who we- re not suitable for transplantation. This difference was statistically significant (p=0.001). Total bilirubin >5.35 mg/dl, internatio- nal normalized ratio (INR) >3.66 and prothrombin time >23.5 seconds were shown to be the risk factors to predict death. Conclu- sions: Metabolic and infectious etiologies were responsible for most of the acute liver failure cases. Clinical encephalopathy may not be present in children.
Zeren Bariş; Inci Nur Saltik Temızel; Nuray Uslu; Yusuf Usta; Hülya Demır; Figen Gürakan; Hasan Ozen; Aysel Yüce
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology     Volume:  23     ISSN:  1300-4948     ISO Abbreviation:  Turk J Gastroenterol     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-06-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9515841     Medline TA:  Turk J Gastroenterol     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  127-34     Citation Subset:  IM    
Gazi University Hospital, Pediatric Gastroenterology, Ankara, Turkey.
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