| Acute liver failure in children. | |
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MedLine Citation:
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PMID: 18452115 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute liver failure (ALF) in children differs from that observed in adults in both the etiologic spectrum and the clinical picture. Children, particularly very young ones, do not demonstrate classical features of encephalopathy and the definition of ALF has been revised to include patients with advanced coagulopathy, regardless of mental status. A significant number of these children will go on to require transplant or die. Etiologies vary by age with metabolic and infectious diseases prominent in the first year of life and acetaminophen overdose and Wilson's disease occurring in adolescents. In almost 50% of cases, however, the child has an indeterminate cause for ALF. Management requires a multidisciplinary approach and is directed at establishing the etiology where possible and monitoring, anticipating, and managing the multisystem complications that occur in children with ALF. Overall, short-term outcomes are better in children than adults but are dependent upon the degree of encephalopathy and diagnosis. |
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Authors:
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Robert H Squires |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Seminars in liver disease Volume: 28 ISSN: 0272-8087 ISO Abbreviation: Semin. Liver Dis. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-02 Completed Date: 2008-09-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8110297 Medline TA: Semin Liver Dis Country: United States |
Other Details:
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Languages: eng Pagination: 153-66 Citation Subset: IM |
Affiliation:
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University of Pittsburgh, Pittsburgh, PA 15213, USA. squiresr@upmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetaminophen
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adverse effects Adrenal Cortex Hormones / therapeutic use Analgesics, Non-Narcotic / adverse effects Child Drug Therapy / adverse effects Humans Immunologic Deficiency Syndromes / complications Infection / complications Liver Failure, Acute / etiology*, therapy* Liver Transplantation Metabolism, Inborn Errors / complications Phytotherapy / adverse effects Plasma Exchange Plasmapheresis Poisons / adverse effects Renal Dialysis |
| Grant Support | |
ID/Acronym/Agency:
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1 U01 DK072146-01/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Analgesics, Non-Narcotic; 0/Poisons; 103-90-2/Acetaminophen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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