Document Detail

Acute limb deterioration during intra-arterial thrombolysis.
MedLine Citation:
PMID:  8402106     Owner:  NLM     Status:  MEDLINE    
Approximately 12 per cent of limbs undergoing intra-arterial thrombolysis (IAT) develop distal embolism or extension of thrombus during the procedure. These are usually of little clinical consequence and can be treated by increasing the rate of administration of the lytic agent. However, in some patients the clinical condition of the limb deteriorates rapidly. In an attempt to define the incidence of acute limb deterioration during IAT, information was collected from five centres in the UK with experience of the technique. A total of 866 treatments were recorded, with 20 limbs (2.3 per cent) undergoing acute deterioration. This complication was more common during the treatment of thrombosed popliteal aneurysm than during that of emboli or thrombosed atheromatous arteries or grafts (P < 0.001). The amputation rate associated with the complication was high, and operative intervention provided better results than continuation of lysis.
R B Galland; J J Earnshaw; R N Baird; R J Lonsdale; B R Hopkinson; A E Giddings; K J Dawson; G Hamilton
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  The British journal of surgery     Volume:  80     ISSN:  0007-1323     ISO Abbreviation:  Br J Surg     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-11-22     Completed Date:  1993-11-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372553     Medline TA:  Br J Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1118-20     Citation Subset:  AIM; IM    
Department of Surgery, Royal Berkshire Hospital, Reading, UK.
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MeSH Terms
Aneurysm / complications
Ischemia / chemically induced*
Leg / blood supply
Popliteal Artery
Thrombolytic Therapy / adverse effects*
Vascular Patency

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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