| Acute life-threatening cardiovascular toxicity with umbilical cord blood infusion: the role of dextran. | |
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MedLine Citation:
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PMID: 20661918 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Umbilical cord blood (UCB) is being increasingly used for hematopoietic stem cell transplantation due to its immediate availability. Dimethylsulfoxide (DMSO) and dextran-40 are commonly used for processing and cryopreservation of UCB. Adverse UCB infusion-related events are usually mild. However, reports of severe life-threatening events are now emerging. DMSO has been proposed as a possible cause of infusion-related reactions. In this report, we draw attention to an acute near-fatal reaction with UCB infusions resulting in myocardial ischemia and acute renal failure. We propose that dextran-40 in UCB infusion products be considered as a potential causative agent contributing to this infusion-related reaction, based on reports of known adverse reactions to dextran-40 in non-transplant settings. |
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Authors:
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Robert W Ma; John M Kwan; David D Ma; Keith C Fay |
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Publication Detail:
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Type: Letter |
Journal Detail:
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Title: American journal of hematology Volume: 85 ISSN: 1096-8652 ISO Abbreviation: Am. J. Hematol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-14 Completed Date: 2010-10-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7610369 Medline TA: Am J Hematol Country: United States |
Other Details:
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Languages: eng Pagination: 722-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cord Blood Stem Cell Transplantation* Dextrans / administration & dosage, adverse effects* Female Hematologic Neoplasms / therapy Humans Male Middle Aged Myocardial Ischemia / chemically induced* Plasma Substitutes / administration & dosage, adverse effects* Transplantation, Homologous |
| Chemical | |
Reg. No./Substance:
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0/Plasma Substitutes; 9004-54-0/Dextrans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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