Document Detail

Acute leukemia presenting with blasts first found in the cerebrospinal fluid but not in the peripheral blood.
MedLine Citation:
PMID:  20605098     Owner:  NLM     Status:  MEDLINE    
Acute leukemia presenting with central nervous system (CNS) signs and symptoms is uncommon and prone to be misdiagnosed. Here, we report nine patients with acute leukemia, including five patients with acute lymphoblastic leukemia (ALL) and four patients with acute myeloid leukemia (AML). These patients presented with symptoms suggestive of involvement of multiple cranial nerves, the spinal cord, and meningeal involvement. Moreover, we found that all these patients unexpectedly showed the presence of blasts in the cerebrospinal fluid (CSF) but not in the peripheral blood despite repeated examinations. Bone marrow examination confirmed the presence of acute leukemia in these patients. Seven patients died within 18months of diagnosis and two patients developed stable disease. Our findings show a novel presenting feature of acute leukemia and highlight the importance of CSF cytology in the diagnosis of acute leukemia.
Haoran Cheng; Yining Yang; Wen Dai; Chi Tang; Ming Shi; Guodong Feng; Tao Kang; Xiuchu Su; Gang Zhao
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia     Volume:  17     ISSN:  1532-2653     ISO Abbreviation:  J Clin Neurosci     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-08-16     Completed Date:  2010-12-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433352     Medline TA:  J Clin Neurosci     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  1252-5     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.
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MeSH Terms
Acute Disease
Child, Preschool
Cranial Nerve Diseases / blood,  cerebrospinal fluid,  etiology
Leukemia / blood,  cerebrospinal fluid*,  complications,  diagnosis*
Retrospective Studies
Spinal Cord / pathology
Young Adult

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