| Acute leukemia in pregnancy: transient neonatal myelosuppression after combination chemotherapy in the mother. | |
| | |
MedLine Citation:
|
PMID: 296785 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
An 18-year-old primagravida received combination chemotherapy with vincristine, prednisone, L-asparaginase, cyclophosphamide, daunomycin, 6-mercaptopurine and central nervous system (CNS) prophylaxis with intrathecal methotrexate and whole-brain irradiation for acute lymphoblastic leukemia (ALL) beginning in the 12th week of pregnancy. Therapy resulted in sustained complete remission of the leukemia and delivery of a normally developed female infant whose immediate neonatal course was complicated by transient severe bone marrow hypoplasia. Our experience confirms the reports of others that intensive chemotherapy can be administered in the last two trimesters of pregnancy without serious teratogenic complications. However, we conclude that such therapy may cause significant myelosuppression in the newborn. |
| | |
Authors:
|
D B Okun; P K Groncy; L Sieger; K R Tanaka |
Related Documents
:
|
1455285 - Mumps encephalomyelitis. 22115165 - Pregnancy and other pituitary disorders (including gh deficiency). 11229185 - Cerebral venous thrombosis in pregnancy and puerperium--a prospective study. 3618685 - Acute atherosis in preeclampsia: maternal determinants and fetal outcome in the presenc... 10696955 - Hemoglobin and erythrocyte indices during normal pregnancy and postpartum in 206 women ... 12476455 - De novo dup(x)(q22.3q26) in a girl with evidence that functional disomy of x material i... |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Medical and pediatric oncology Volume: 7 ISSN: 0098-1532 ISO Abbreviation: Med. Pediatr. Oncol. Publication Date: 1979 |
Date Detail:
|
Created Date: 1980-08-25 Completed Date: 1980-08-25 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7506654 Medline TA: Med Pediatr Oncol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 315-9 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antineoplastic Agents
/
administration & dosage,
adverse effects Bone Marrow Diseases / etiology* Drug Therapy, Combination Female Humans Infant, Newborn Infant, Premature, Diseases / etiology* Leukemia, Lymphoid / complications*, drug therapy Maternal-Fetal Exchange* Pregnancy Pregnancy Complications, Hematologic* |
| Chemical | |
Reg. No./Substance:
|
0/Antineoplastic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Micrococcus luteus pneumonia: a case report and review of the literature.
Next Document: L-asparaginase effect on antithrombin-III levels.