| Acute leukemia during pregnancy: a report on 37 patients and a review of the literature. | |
| | |
MedLine Citation:
|
PMID: 15912518 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Acute leukemia (AL) requiring cytotoxic treatment occurring during pregnancy poses a very difficult therapeutic dilemma. METHODS: By means of a mail questionnaire, information on a series of 37 patients with a diagnosis of AL during pregnancy was collected from 13 French centers between December, 1988 and November, 2003. RESULTS: Thirty-one patients had acute myeloid leukemia (AML), and 6 patients had acute lymphoblastic leukemia (ALL). Nine patients were diagnosed during the first trimester, 10 patients were diagnosed during the second trimester, and 18 patients were diagnosed during the third trimester. Fifteen pregnancies ended with therapeutic or spontaneous abortion. There were 13 normal deliveries, including 1 gemellary pregnancy, and 9 Cesarean sections. Twenty-three healthy babies survived from the 37 pregnancies, of whom 15 babies had been exposed to chemotherapeutic agents. A complete remission was achieved in 34 patients. Eleven women had severe extrahematologic complications during the induction remission course. The median disease-free survival (DFS) was not reached, with a 5-year DFS of 54%. Ten patients developed recurrent disease. Overall, 12 of 37 pregnant women died from leukemia. CONCLUSIONS: Pregnancy does not affect the course of AL. In the first trimester, termination of pregnancy should be discussed because of the potential fetal consequences of chemotherapy. Chemotherapy treatment during the second or third trimester may not require termination of pregnancy, because as remission of AL and delivery of a normal infant are likely to be obtained. |
| | |
Authors:
|
Youcef Chelghoum; Norbert Vey; Emmanuel Raffoux; Françoise Huguet; Arnaud Pigneux; Brigitte Witz; Cécile Pautas; Stéphane de Botton; Denis Guyotat; Bruno Lioure; Nathalie Fegueux; Frédéric Garban; Hussam Saad; Xavier Thomas |
Related Documents
:
|
6584858 - Chemotherapy for acute leukemia during pregnancy. five case reports. 15970898 - Serious pregnancy complications in a patient with previously undiagnosed carnitine palm... 8018608 - Transient diabetes insipidus and acute fatty liver of pregnancy. 4615858 - Leukemia in pregnancy. 3024688 - Assessment of the datex relaxograph during anaesthesia and atracurium-induced neuromusc... 3318658 - Drugs in feto maternal medicine. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Cancer Volume: 104 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 2005 Jul |
Date Detail:
|
Created Date: 2005-06-27 Completed Date: 2005-08-22 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0374236 Medline TA: Cancer Country: United States |
Other Details:
|
Languages: eng Pagination: 110-7 Citation Subset: AIM; IM |
Affiliation:
|
Service d'Hématologie Clinique, Hôpital Edouard Herriot, Lyon, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Disease Adult Antineoplastic Combined Chemotherapy Protocols / adverse effects, therapeutic use Female Humans Leukemia / drug therapy* Leukemia, Myeloid / drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy* Pregnancy Pregnancy Complications, Neoplastic* Pregnancy Outcome Pregnancy Trimesters Remission Induction |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Increased plasma levels of angiogenin and the risk of bladder carcinoma: from initiation ot recurren...
Next Document: Gelatin/chondroitin-6-sulfate copolymer scaffold for culturing human nucleus pulposus cells in vitro...