Document Detail

Acute leukemia during pregnancy. Association with immune-mediated thrombocytopenia in mother and infant.
MedLine Citation:
PMID:  1691571     Owner:  NLM     Status:  MEDLINE    
A 29-year-old female in the 20th week of pregnancy was admitted because of a change in the ABO blood group and bleeding tendency. Acute myelogenous leukemia was diagnosed with a weak reaction of red blood cells with anti-A antibody and a decreased level of A-transferase activity. Though the patient tolerated intensive chemotherapy and achieved complete remission, thrombocytopenia persisted after consolidation chemotherapy. Since platelet-associated IgG was elevated, thrombocytopenia was considered to be immune-mediated. In the third trimester, premature separation of the normally implanted placenta developed and cesarean section was performed. The male baby was also thrombocytopenic, but successfully treated with gamma-globulin.
H Gondo; Y Hamasaki; H Nakayama; T Kondo; J Mitsuuchi; Y Kawaga; S Taniguchi; M Harada; Y Niho
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta haematologica     Volume:  83     ISSN:  0001-5792     ISO Abbreviation:  Acta Haematol.     Publication Date:  1990  
Date Detail:
Created Date:  1990-05-21     Completed Date:  1990-05-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0141053     Medline TA:  Acta Haematol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  140-4     Citation Subset:  IM    
Division of Internal Medicine, Sanshinkai Hara Hospital, Fukuoka, Japan.
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MeSH Terms
Abruptio Placentae / etiology
Cesarean Section
Infant, Newborn
Leukemia, Myeloid, Acute / blood*,  drug therapy
Pregnancy Complications, Hematologic / etiology*,  therapy
Pregnancy Complications, Neoplastic / blood*,  drug therapy
Pregnancy Trimester, Third
Thrombocytopenia / congenital,  etiology*,  therapy
gamma-Globulins / therapeutic use
Reg. No./Substance:

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