| Acute leukaemia in bcr/abl transgenic mice. | |
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MedLine Citation:
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PMID: 2179728 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Philadelphia chromosome, widely implicated in human leukaemia, is the result of a reciprocal translocation t(9;22) (q34;q11) in which the abl oncogene located at 9q34 is translocated to chromosome 22q11, where it is fused head-to-tail with 5' exons of the bcr gene. In acute lymphoblastic leukaemia, some patients have a breakpoint within the major breakpoint cluster region of the bcr gene, whereas others have the break within its first intron. This second type of translocation results in the transcription of a 7.0-kilobase chimaeric bcr/abl messenger RNA translated into a bcr/abl fusion protein, p190, which has an abnormal tyrosine kinase activity and is strongly autophosphorylated in vitro. We have generated mice transgenic for a bcr/abl p190 DNA construct and find that progeny are either moribund with, or die of acute leukaemia (myeloid or lymphoid) 10-58 days after birth. This finding is evidence for a causal relationship between the Philadelphia chromosome and human leukaemia. |
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Authors:
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N Heisterkamp; G Jenster; J ten Hoeve; D Zovich; P K Pattengale; J Groffen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Nature Volume: 344 ISSN: 0028-0836 ISO Abbreviation: Nature Publication Date: 1990 Mar |
Date Detail:
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Created Date: 1990-04-20 Completed Date: 1990-04-20 Revised Date: 2012-06-25 |
Medline Journal Info:
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Nlm Unique ID: 0410462 Medline TA: Nature Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 251-3 Citation Subset: IM |
Affiliation:
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Department of Pathology, Children's Hospital, Los Angeles, California 90027. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals B-Lymphocytes / pathology Bone Marrow / pathology Cloning, Molecular Leukemia, Experimental / genetics* Leukemia, Myeloid, Acute / genetics, pathology Mice Mice, Transgenic Philadelphia Chromosome* Phosphorylation Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics, pathology Protein-Tyrosine Kinases* Proto-Oncogene Proteins / genetics* Proto-Oncogene Proteins c-abl Proto-Oncogene Proteins c-bcr RNA, Messenger / genetics Recombinant Fusion Proteins / genetics Transfection Translocation, Genetic |
| Chemical | |
Reg. No./Substance:
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0/Proto-Oncogene Proteins; 0/RNA, Messenger; 0/Recombinant Fusion Proteins; EC 2.7.10.1/Protein-Tyrosine Kinases; EC 2.7.10.2/Proto-Oncogene Proteins c-abl; EC 2.7.11.1/Bcr protein, mouse; EC 2.7.11.1/Proto-Oncogene Proteins c-bcr |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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