Document Detail

Acute leukaemia in bcr/abl transgenic mice.
MedLine Citation:
PMID:  2179728     Owner:  NLM     Status:  MEDLINE    
The Philadelphia chromosome, widely implicated in human leukaemia, is the result of a reciprocal translocation t(9;22) (q34;q11) in which the abl oncogene located at 9q34 is translocated to chromosome 22q11, where it is fused head-to-tail with 5' exons of the bcr gene. In acute lymphoblastic leukaemia, some patients have a breakpoint within the major breakpoint cluster region of the bcr gene, whereas others have the break within its first intron. This second type of translocation results in the transcription of a 7.0-kilobase chimaeric bcr/abl messenger RNA translated into a bcr/abl fusion protein, p190, which has an abnormal tyrosine kinase activity and is strongly autophosphorylated in vitro. We have generated mice transgenic for a bcr/abl p190 DNA construct and find that progeny are either moribund with, or die of acute leukaemia (myeloid or lymphoid) 10-58 days after birth. This finding is evidence for a causal relationship between the Philadelphia chromosome and human leukaemia.
N Heisterkamp; G Jenster; J ten Hoeve; D Zovich; P K Pattengale; J Groffen
Related Documents :
1065618 - Non-random karyotypic evolution in chronic myeloid leukemia.
8251918 - Animal models of bcr/abl-induced leukemias.
2179728 - Acute leukaemia in bcr/abl transgenic mice.
12654978 - Periventricular heterotopia associated with chromosome 5p anomalies.
18617058 - Monosomy 7 and absence of 12q amplification in two cases of spindle cell liposarcomas.
12533818 - The clinical application of spectral karyotyping (sky) in the analysis of prenatally di...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nature     Volume:  344     ISSN:  0028-0836     ISO Abbreviation:  Nature     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-04-20     Completed Date:  1990-04-20     Revised Date:  2012-06-25    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  251-3     Citation Subset:  IM    
Department of Pathology, Children's Hospital, Los Angeles, California 90027.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
B-Lymphocytes / pathology
Bone Marrow / pathology
Cloning, Molecular
Leukemia, Experimental / genetics*
Leukemia, Myeloid, Acute / genetics,  pathology
Mice, Transgenic
Philadelphia Chromosome*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics,  pathology
Protein-Tyrosine Kinases*
Proto-Oncogene Proteins / genetics*
Proto-Oncogene Proteins c-abl
Proto-Oncogene Proteins c-bcr
RNA, Messenger / genetics
Recombinant Fusion Proteins / genetics
Translocation, Genetic
Reg. No./Substance:
0/Proto-Oncogene Proteins; 0/RNA, Messenger; 0/Recombinant Fusion Proteins; EC Kinases; EC Proteins c-abl; EC protein, mouse; EC Proteins c-bcr

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of hemipancreatectomy on insulin secretion and glucose tolerance in healthy humans.
Next Document:  Enhanced myogenesis in NCAM-transfected mouse myoblasts.