Document Detail

Acute lead encephalopathy in early infancy--clinical presentation and outcome.
MedLine Citation:
PMID:  9176576     Owner:  NLM     Status:  MEDLINE    
We studied 19 infants with a mean age of 3.8 months who presented with features consistent with acute lead encephalopathy following the use of traditional medicines. All presented with convulsions; CT scans of the brain on admission showed brain oedema in four, atrophy in four and normal findings in 11. Cerebrospinal fluid analysis in nine patients showed pleocytosis in six and a high protein content in eight. The median lead level in these 19 infants which encephalopathy was 3.6 mumol/l (74.5 micrograms/dl). Seven had a mean lead level of only 2.7 mumol/l (56.9 micrograms/dl) which is much below 70 micrograms/dl, the level usually proposed as the threshold for encephalopathy. Thirteen infants developed brain damage during follow-up; statistical analysis correlated the lead level at 2 months post chelation with an abnormal neurological outcome. Our findings indicate that in very young infants acute lead encephalopathy may occur at lead level lower than previously reported.
A al Khayat; N S Menon; M R Alidina
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of tropical paediatrics     Volume:  17     ISSN:  0272-4936     ISO Abbreviation:  Ann Trop Paediatr     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-06-16     Completed Date:  1997-06-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8210625     Medline TA:  Ann Trop Paediatr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  39-44     Citation Subset:  IM    
Department of Pediatrics, Al Wasl Maternity & Pediatric Hospital, Dubai, United Arab Emirates.
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MeSH Terms
Brain Diseases / blood,  chemically induced*,  therapy
Child Development
Lead / blood
Lead Poisoning / blood,  complications*,  therapy
Logistic Models
Medicine, Traditional
Retrospective Studies
Risk Factors
United Arab Emirates
Reg. No./Substance:

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