Document Detail

Acute and late effects of 16- and 50-MeVd leads to Be neutrons on the oral mucosa of rhesus monkeys.
MedLine Citation:
PMID:  808830     Owner:  NLM     Status:  MEDLINE    
Twenty-five rhesus monkeys were randomly assigned to one of five treatment schedules: 1. control group, no irradiation, 2. 60Co five times weekly, 3. 60Co twice weekly, 4. 16-MeVd leads to Be neutrons twice weekly, and 5. 50-MeVd leads to Be neutrons twice weekly. Although the acute reactions were similar in the four irradiated groups, the late sequelae were more severe in the animals irradiated twice weekly with 60Co or neutrons. All of the animals irradiated with 60Co twice weekly or with 16 MeVd leads to Be neutrons exhibited oromucosal necrosis, whereas none of those irradiated five times weekly with 60Co did. The difference in the effect of photon fractionation on early and late radiation sequelae may be related to different patterns of redistribution of surviving cells through the division cycle in tissues responsible for early and late damage.
J H Jardine; D H Hussey; D D Boyd; G L Raulston; T J Davidson
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Radiology     Volume:  117     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  1975 Oct 
Date Detail:
Created Date:  1975-11-22     Completed Date:  1975-11-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  185-91     Citation Subset:  AIM; IM    
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MeSH Terms
Cobalt Radioisotopes
Dose-Response Relationship, Radiation
Erythema / etiology
Fast Neutrons
Gingiva / pathology
Gingivitis, Necrotizing Ulcerative / etiology*
Macaca mulatta
Mouth Diseases / etiology
Mouth Mucosa / radiation effects*
Necrosis / etiology
Radiation Dosage
Radiation Injuries, Experimental*
Time Factors
Reg. No./Substance:
0/Cobalt Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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