Document Detail

Acute isovolemic anemia in anesthetized chickens.
MedLine Citation:
PMID:  998789     Owner:  NLM     Status:  MEDLINE    
Acute isovolemic anemia was produced in anesthetized chickens by serial exchanges of 6% dextran 70 equal to 1% of body weight to quantitate cardiovascular and metabolic parameters. When hematocrit (Hct) and hemoglobin (Hb) levels were reduced by 50% (from 33.3 to 16.3 vol %, and from 10.3 to 5.4 g/100 g, respectively, P less than 0.001), tissue oxygen delivery was maintained by increases in cardiac output (CO), stroke volume (SV), oxygen extraction, and reduced total peripheral resistance (TPR). Heart rate, right atrial pressure, and oxygen consumption (Vo2) were unchanged. Further reductions in Hct and Hb (to 10.8 vol % and 3.7 g/100 g, respectively), were accompanied by cardiovascular failure, as evidenced by falling CO, SV, tissue oxygen delivery, and Vo2. Relative apparent viscosity determinations on the exchanged blood-dextran mixtures indicated that large viscosity changes occurred with the first exchange whereas subsequent exchanges had small incremental viscosity changes. These data indicate that in acutely anemic chickens, oxygen transport capacity was maintained by increased cardiac output and decreased peripheral resistance, unless the severity of the anemia resulted in cardiovascular failure.
T E Nightingale
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  231     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1976 Nov 
Date Detail:
Created Date:  1977-01-29     Completed Date:  1977-01-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1451-6     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Anemia / blood,  etiology,  physiopathology,  veterinary*
Blood Pressure
Blood Viscosity
Cardiac Output
Electrolytes / analysis,  blood
Heart Rate
Hemoglobins / analysis
Osmolar Concentration
Oxygen / blood
Plasma Substitutes / analysis
Poultry Diseases / blood,  physiopathology*
Reg. No./Substance:
0/Electrolytes; 0/Hemoglobins; 0/Plasma Substitutes; 7782-44-7/Oxygen; 9004-54-0/Dextrans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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