Document Detail

Acute intoxication due to ibuprofen overdose.
MedLine Citation:
PMID:  3755329     Owner:  NLM     Status:  MEDLINE    
A male patient ingested a single overdose of ibuprofen (greater than 20 g). The serum ibuprofen levels were 185 mg/L (897 mumol/L) and 51.6 mg/L (250 mumol/L) at ten hours and 67 hours, respectively, after ingestion. There was also an accumulation of metabolites (2-carboxyibuprofen and 2-hydroxyibuprofen) in the plasma. The patient became unresponsive and developed severe metabolic acidosis, acute renal failure, acute liver-cell injury, acute cholestasis, and thrombocytopenia. Although his course was complicated by respiratory failure, hypotension, and upper gastrointestinal tract bleeding, the patient had complete resolution of multiple organ failure.
C Y Lee; A Finkler
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  110     ISSN:  0003-9985     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-08-15     Completed Date:  1986-08-15     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  747-9     Citation Subset:  AIM; IM    
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MeSH Terms
Acidosis / chemically induced,  physiopathology
Cholestasis / chemically induced,  physiopathology
Drug-Induced Liver Injury
Ibuprofen / poisoning*
Kidney Failure, Acute / chemically induced,  physiopathology
Liver Diseases / physiopathology
Liver Function Tests
Multiple Organ Failure / physiopathology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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