Document Detail

Acute interstitial pneumopathy associated with docetaxel hypersensitivity.
MedLine Citation:
PMID:  15591716     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Acute pulmonary toxicity in cancer patients treated with docetaxel has been reported in previous phase II studies and case reports. Unlike transient pulmonary infiltrates, it is demonstrated that docetaxel-induced interstitial pneumopathy is a severe clinical condition that generally leads to respiratory failure.
CASE REPORT: We report a patient with breast cancer who received 2 cycles of docetaxel in 3-week intervals and developed respiratory failure. The clinical, pathologic, and radiographic data supported pulmonary toxicity caused by a hypersensitivity reaction to docetaxel as the most likely etiology. The patient developed the same symptoms and radiological findings after 1 cycle of paclitaxel administration. Unlike other more severe examples in the literature, this patient's condition did not require mechanical ventilation, and she recovered after corticosteroid treatment.
CONCLUSION: The present case raises the possibility that taxanes, as a group of chemotherapeutic agents, may cause the same type of adverse reaction in the pulmonary parenchyma. The authors recommend that any patient who develops a taxane-induced pulmonary toxic reaction, not be rechallenged or treated with another agent of the same class.
O Karacan; F O Eyüboglu; S Akçay; O Ozyilkan
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Onkologie     Volume:  27     ISSN:  0378-584X     ISO Abbreviation:  Onkologie     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-13     Completed Date:  2005-02-15     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  7808556     Medline TA:  Onkologie     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  563-5     Citation Subset:  IM    
Department of Pulmonary Diseases, Başkent University Faculty of Medicine, Ankara, Turkey.
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MeSH Terms
Acute Disease
Antineoplastic Agents / administration & dosage*,  adverse effects*
Breast Neoplasms / drug therapy*
Carcinoma, Ductal / drug therapy
Dose-Response Relationship, Drug
Drug Hypersensitivity / complications*,  diagnosis
Lung Diseases, Interstitial / chemically induced*,  diagnosis
Taxoids / adverse effects*,  therapeutic use*
Reg. No./Substance:
0/Antineoplastic Agents; 0/Taxoids; 15H5577CQD/docetaxel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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