Document Detail

Acute interstitial nephritis related to lansoprazole administration.
MedLine Citation:
PMID:  18655432     Owner:  NLM     Status:  MEDLINE    
Acute interstitial nephritis (AIN) is a rare but serious adverse effect reported with proton pump inhibitors (PPIs). Only one report (2 cases) of AIN with lansoprazole is published in literature. A case of lansoprazole induced interstitial nephritis (biopsy supported) was reported in an elderly female patient admitted to the hospital with non specific symptoms after 45 days of treatment with the drug. A recovery was noticed upon withdrawal of the drug and treatment with corticosteroids. We consider this report as a valuable addition to the existing literature on this rare adverse effect with lansoprazole. This potentially serious adverse effect with PPIs including lansoprazole has to be given due consideration, especially taking into account the wide spread use of this group of agents.
Jimmy Jose; Kavitha Saravu; Kanav Khera; Beena Jimmy; Barkur Anantha Krishna Shastry
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  JPMA. The Journal of the Pakistan Medical Association     Volume:  58     ISSN:  0030-9982     ISO Abbreviation:  J Pak Med Assoc     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-07-28     Completed Date:  2008-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7501162     Medline TA:  J Pak Med Assoc     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  206-7     Citation Subset:  IM    
Dcpartmcnt of Clinical Pharmacy, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
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MeSH Terms
2-Pyridinylmethylsulfinylbenzimidazoles / adverse effects*
Acute Disease
Anti-Ulcer Agents / adverse effects*
Nephritis, Interstitial / chemically induced*,  diagnosis*
Reg. No./Substance:
0/2-Pyridinylmethylsulfinylbenzimidazoles; 0/Anti-Ulcer Agents; 103577-45-3/lansoprazole

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