| Acute interstitial nephritis predisposed a six-year-old girl to minimal change nephrotic syndrome. | |
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MedLine Citation:
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PMID: 15942794 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A six-year-old girl was admitted to our hospital with acute renal failure. We made a clinical diagnosis of acute interstitial nephritis and oral corticosteroid therapy was started. Her renal failure soon recovered, and renal biopsy showed acute interstitial nephritis by light microscopy with glomerular foot process effacement by electron microscopy. Although her proteinuria was not heavy at the time of biopsy, her proteinuria subsequently increased to show nephrotic syndrome. We continued to give corticosteroids and her nephrotic syndrome went into remission 13 days after biopsy. Serological and bacteriological examination showed no evidence of known pathogen or drug hypersensitivity. The time changes in proteinuria were monitored by fractional total protein excretion (FETP) and fractional beta2 microglobulin excretion (FEbeta2MG) in order to evaluate the severity of proteinuria under different glomerular filtration rates and different proximal tubular functions. The results revealed that nephrotic syndrome had occurred during recovery from acute interstitial nephritis. This is the first case report to show the sequential occurrence of acute interstitial nephritis and nephrotic syndrome based on evidence from fractional protein excretion. |
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Authors:
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Shori Takahashi; Tomomi Kitamura; Hitohiko Murakami; Koji Hashimoto; Michio Nagata; Kensuke Harada |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2005-06-08 |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 20 ISSN: 0931-041X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-07-08 Completed Date: 2005-11-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: Germany |
Other Details:
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Languages: eng Pagination: 1168-70 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Nihon University School of Medicine, Tokyo, Japan. shori@med.nihon-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Child Female Humans Kidney / pathology Nephritis, Interstitial / complications* Nephrosis, Lipoid / etiology* Proteinuria / diagnosis beta 2-Microglobulin / urine |
| Chemical | |
Reg. No./Substance:
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0/beta 2-Microglobulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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