Document Detail

Acute inflammatory demyelinating optic neuritis: current concepts in diagnosis and management.
MedLine Citation:
PMID:  16198993     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Optic neuritis (ON), defined as an inflammatory demyelinating optic neuropathy, is a frequent cause of visual loss owing to optic nerve dysfunction in young or middle-aged patients. ON can be seen in isolation or in association with multiple sclerosis (MS). Highlighting the importance of this association is the fact that approximately 20% of patients with MS will present with ON. METHODS: Review was conducted of the literature and pertinent clinical trials. CONCLUSION: Although the vision prognosis of patients with ON is excellent, with or without the use of corticosteroids, a minority of patients will suffer from significantly poor vision. ON may be the heralding manifestation of MS; the risk stratification for the future development of MS in patients presenting with ON can be determined by the number of white matter lesions on the baseline cerebral magnetic resonance imaging study. To date, 2 randomized, placebo-controlled studies have found that patients with a clinically isolated demyelinating syndrome, such as ON, at risk for MS, may benefit from the early institution of a disease-modifying drug.
M Tariq Bhatti; Nicholas J Schmitt; Randall L Beatty
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Optometry (St. Louis, Mo.)     Volume:  76     ISSN:  1529-1839     ISO Abbreviation:  Optometry     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-10-03     Completed Date:  2005-11-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100912421     Medline TA:  Optometry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  526-35     Citation Subset:  IM    
Department of Ophthalmology, University of Florida College of Medicine, Gainesville, Florida 32610, USA.
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MeSH Terms
Acute Disease
Demyelinating Diseases* / diagnosis,  drug therapy
Diagnosis, Differential
Drug Administration Routes
Drug Administration Schedule
Follow-Up Studies
Glucocorticoids / administration & dosage,  therapeutic use*
Magnetic Resonance Imaging
Methylprednisolone / administration & dosage,  therapeutic use*
Optic Nerve / pathology
Optic Neuritis* / diagnosis,  drug therapy
Prednisolone / administration & dosage,  therapeutic use*
Visual Acuity
Reg. No./Substance:
0/Glucocorticoids; 50-24-8/Prednisolone; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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