Document Detail

Acute infantile pneumonopathies treated with fosfomycin.
MedLine Citation:
PMID:  832530     Owner:  NLM     Status:  MEDLINE    
Reference is made to the results obtained in 24 children, from 11 months to 12 years, affected with acute pneumopathies and treated with fosfomycin with a dosage of 200 mg/kg/day. In all cases a clinical, radiological, biological and bacteriological study was carried out. At the same time, levels of fosfomycin in plasma and sputum were checked every 5 days during the course of treatment. In the 4 cases of pleurisy the level of antibiotic in the pleural liquid was also checked. The concentration of fosfomycin in the sputum gives very variable results with average values oscillating between 16.5 and 23.4% of the plasmatic level respectively at the beginning and end of treatment, a cumulative effect of the antibiotic being observed. Concentration in pleural liquid oscillates between 39 and 50%. The clinical, radiological and biological evolution has been favourable iin 21 cases, unfavourable in two cases and in one case treatment had to be suspended because of the apparition of a cutaneous necrosis. Apart from this case no notable toxic effects were observed. Children do not support intramuscular injections very well and intravenous injections often cause phlebitis.
J Llorens; G Ley; A Forés; T Olay
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemotherapy     Volume:  23 Suppl 1     ISSN:  0009-3157     ISO Abbreviation:  Chemotherapy     Publication Date:  1977  
Date Detail:
Created Date:  1977-03-31     Completed Date:  1977-03-31     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0144731     Medline TA:  Chemotherapy     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  315-23     Citation Subset:  IM    
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MeSH Terms
Anti-Bacterial Agents / therapeutic use*
Bronchitis / drug therapy
Child, Preschool
Drug Evaluation
Fosfomycin / adverse effects,  metabolism,  therapeutic use*
Pleura / metabolism
Pleurisy / drug therapy
Pneumonia / drug therapy
Respiratory Tract Infections / drug therapy*,  metabolism
Sputum / analysis
Tracheitis / drug therapy
Reg. No./Substance:
0/Anti-Bacterial Agents; 23155-02-4/Fosfomycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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