| Acute increases in anastomotic bronchial systemic to pulmonary blood flow due to generalized lung injury. | |
| | |
MedLine Citation:
|
PMID: 3301787 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Since pulmonary blood flow to regions involved in adult respiratory disease syndrome (ARDS) is reduced by hypoxic vasoconstriction, compression by cuffs of edema, and local thromboses, we postulated that the bronchial circulation must enlarge to provide for the inflammatory response. We measured anastomotic bronchial systemic to pulmonary blood flow [QBr(s-p)] serially in a lung lobe in 31 open-chest dogs following a generalized lobar injury simulating ARDS. The pulmonary circulation of the weighed left lower lobe (LLL) was isolated and perfused (zone 2) with autologous blood in anesthetized dogs. QBr(s-p) was measured from the amount of blood which overflowed from this closed vascular circuit corrected by any changes in the lobe weight. The LLL was ventilated with 5% CO2 in air. The systemic blood pressure (volume infusion), gases, and acid-base status (right lung ventilation) were kept constant. We injured the LLL via the airway by instilling either 0.1 N HCl or a mixture of glucose and glucose oxidase or via the pulmonary vessels by injecting either alpha-naphthylthiourea or oleic acid into the LLL pulmonary artery. In both types of injury, there was a prompt rise in QBr(s-p) (mean rise = 247% compared with control), which was sustained for the 2 h of observation. The cause of this increase in flow was studied. Control instillation of normal saline into the airways or into the pulmonary vessels did not change QBr(s-p) nor did a similar increase in lobar fluid (weight) due to hydrostatic edema. Neither cardiac output nor systemic blood pressure increased.(ABSTRACT TRUNCATED AT 250 WORDS) |
| | |
Authors:
|
S Lakshminarayan; S K Jindal; W Kirk; J Butler |
Related Documents
:
|
9572797 - Pulmonary blood flow distribution during partial liquid ventilation. 1490957 - Role of pulmonary blood flow in postpneumonectomy lung growth. 8391767 - Regional danofloxacin lung tissue concentrations and their relationship to regional pul... 3968017 - Partitioning of respiratory mechanics in halothane-anesthetized humans. 14991667 - Studies on acute human infections using ftir microspectroscopy and cluster analysis. 19730977 - Comparison of pesticide exposure and physical examination, neurological assessment, and... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 62 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1987 Jun |
Date Detail:
|
Created Date: 1987-08-28 Completed Date: 1987-08-28 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 2358-61 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Bronchi / blood supply Dogs Female Lung Injury* Male Positive-Pressure Respiration Pulmonary Circulation* Pulmonary Edema / physiopathology Regional Blood Flow Respiratory Distress Syndrome, Adult / physiopathology |
| Grant Support | |
ID/Acronym/Agency:
|
HL-30542/HL/NHLBI NIH HHS; TW-03141/TW/FIC NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Does indomethacin affect shunt and its response to PEEP in oleic acid pulmonary edema?
Next Document: Neural control of contraction in isolated submucosal gland from feline trachea.