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Acute immune response in respect to exercise-induced oxidative stress.
MedLine Citation:
PMID:  11228396     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The relationship between exhaustive exercise, oxidative stress, the protective capacity of the antioxidant defense system and cellular immune response has been determined. Exhaustive exercise in well-trained young men (n=19)-induced leukocytosis, decreased proportion of activated-lymphocyte subsets (CD4+ and CD8+) expressing CD69, decreased lymphocyte mitogenic response to concanavalin A (ConA) and phytohemagglutinin (PHA), increased lipid peroxidation, increased total antioxidant status (TAS) and catalase activity, immediately after exercise. Suppressed blood concentration of T-lymphocyte subsets (CD3+, CD4+, CD8+, NK), increased TAS and blood total glutathione (TGSH) in early recovery period (30 min after exercise) were found. Strong positive correlation was observed between TGSH and lymphocyte mitogenic response to ConA and PHA (r=0.85 and 0.85, respectively) immediately after exercise. Moderate positive correlation was observed between TAS and lymphocyte mitogenic response to PHA (r=0.59) immediately after exercise as well as between TAS and lymphocyte mitogenic response to PHA and ConA (r=0.69 and 0.54, respectively). Moderate to weak correlation was observed between TAS and conjugated dienes with exercise (r=0.66) as well as in 30-min recovery (r=0.50). After a short-term bout of exhaustive exercise, immune system was characterized by acute phase response, which was accompanied with oxidative stress. Suppression of the cellular immunity 30 min after exercise shows that this period is not enough for recovery after exhaustive exercise. The results suggest the interactions between exercise-induced oxidative stress and immune response.
Authors:
J Vider; J Lehtmaa; T Kullisaar; T Vihalemm; K Zilmer; C Kairane; A Landõr; T Karu; M Zilmer
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Pathophysiology : the official journal of the International Society for Pathophysiology / ISP     Volume:  7     ISSN:  -     ISO Abbreviation:  Pathophysiology     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-Feb-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433813     Medline TA:  Pathophysiology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  263-270     Citation Subset:  -    
Affiliation:
Department of Sports Medicine and Rehabilitation, 50406, Puusepa la, Estonia
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