| Acute hypoxic pulmonary vasoconstriction in conscious dogs decreases renin and is unaffected by losartan. | |
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MedLine Citation:
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PMID: 10368356 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute hypoxic pulmonary vasoconstriction (HPV) may be mediated by vasoactive peptides. We studied eight conscious, chronically tracheostomized dogs kept on a standardized dietary sodium intake. Normoxia (40 min) was followed by hypoxia (40 min, breathing 10% oxygen, arterial oxygen pressures 36 +/- 1 Torr) during both control (Con) and losartan experiments (Los; iv infusion of 100 microg. min-1. kg-1 losartan). During hypoxia, minute ventilation (by 0.9 l/min in Con, by 1.3 l/min in Los), cardiac output (by 0.36 l/min in Con, by 0.30 l/min in Los), heart rate (by 11 beats/min in Con, by 30 beats/min in Los), pulmonary artery pressure (by 9 mmHg in both protocols), and pulmonary vascular resistance (by 280 and 254 dyn. s. cm-5 in Con and Los, respectively) increased. Mean arterial pressure and systemic vascular resistance did not change. In Con, PRA decreased from 4.2 +/- 0.7 to 2.5 +/- 0.5 ng ANG I. ml-1. h-1, and plasma ANG II decreased from 11.9 +/- 3.0 to 8.2 +/- 2.1 pg/ml. The renin-angiotensin system is inhibited during acute hypoxia despite sympathetic activation. Under these conditions, ANG II AT1-receptor antagonism does not attenuate HPV. |
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Authors:
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M O Krebs; W Boemke; S Simon; M Wenz; G Kaczmarczyk |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 86 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1999 Jun |
Date Detail:
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Created Date: 1999-08-02 Completed Date: 1999-08-02 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1914-9 Citation Subset: IM |
Affiliation:
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Experimental Anesthesia, Clinic of Anesthesiology and Operative Intensive Care Medicine, 13353 Berlin, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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blood Animals Anoxia / blood, physiopathology* Antihypertensive Agents / pharmacology* Bicarbonates / blood Blood Gas Analysis Blood Pressure / physiology Diet Dogs Female Heart Rate / physiology Hemodynamics / physiology Losartan / pharmacology* Plasma Volume / physiology Pulmonary Circulation / physiology* Renin / blood* Respiratory Mechanics / physiology Vascular Resistance / physiology Vasoconstriction / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Bicarbonates; 11128-99-7/Angiotensin II; 114798-26-4/Losartan; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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