Document Detail

Acute hypoxic pulmonary vasoconstriction in conscious dogs decreases renin and is unaffected by losartan.
MedLine Citation:
PMID:  10368356     Owner:  NLM     Status:  MEDLINE    
Acute hypoxic pulmonary vasoconstriction (HPV) may be mediated by vasoactive peptides. We studied eight conscious, chronically tracheostomized dogs kept on a standardized dietary sodium intake. Normoxia (40 min) was followed by hypoxia (40 min, breathing 10% oxygen, arterial oxygen pressures 36 +/- 1 Torr) during both control (Con) and losartan experiments (Los; iv infusion of 100 microg. min-1. kg-1 losartan). During hypoxia, minute ventilation (by 0.9 l/min in Con, by 1.3 l/min in Los), cardiac output (by 0.36 l/min in Con, by 0.30 l/min in Los), heart rate (by 11 beats/min in Con, by 30 beats/min in Los), pulmonary artery pressure (by 9 mmHg in both protocols), and pulmonary vascular resistance (by 280 and 254 dyn. s. cm-5 in Con and Los, respectively) increased. Mean arterial pressure and systemic vascular resistance did not change. In Con, PRA decreased from 4.2 +/- 0.7 to 2.5 +/- 0.5 ng ANG I. ml-1. h-1, and plasma ANG II decreased from 11.9 +/- 3.0 to 8.2 +/- 2.1 pg/ml. The renin-angiotensin system is inhibited during acute hypoxia despite sympathetic activation. Under these conditions, ANG II AT1-receptor antagonism does not attenuate HPV.
M O Krebs; W Boemke; S Simon; M Wenz; G Kaczmarczyk
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  86     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-08-02     Completed Date:  1999-08-02     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1914-9     Citation Subset:  IM    
Experimental Anesthesia, Clinic of Anesthesiology and Operative Intensive Care Medicine, 13353 Berlin, Germany.
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MeSH Terms
Angiotensin II / blood
Anoxia / blood,  physiopathology*
Antihypertensive Agents / pharmacology*
Bicarbonates / blood
Blood Gas Analysis
Blood Pressure / physiology
Heart Rate / physiology
Hemodynamics / physiology
Losartan / pharmacology*
Plasma Volume / physiology
Pulmonary Circulation / physiology*
Renin / blood*
Respiratory Mechanics / physiology
Vascular Resistance / physiology
Vasoconstriction / physiology*
Reg. No./Substance:
0/Antihypertensive Agents; 0/Bicarbonates; 11128-99-7/Angiotensin II; 114798-26-4/Losartan; EC

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