Document Detail

Acute hypertension induces heat-shock protein 70 gene expression in rat aorta.
MedLine Citation:
PMID:  7648669     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Many factors cause acute systemic hypertension, which in turn can result in damage to the vessel wall and lead to vascular disease. In previous studies, we demonstrated that restraint, or immobilization stress, results in the induction of heat-shock protein 70 (hsp70) gene expression in the aorta of adult rat and showed that this response was markedly attenuated with age. METHODS AND RESULTS: Here we provide evidence that restraint-induced hsp70 expression occurs secondary to a rise in systemic blood pressure. Old rats were unable to mount a significant stress-induced hypertensive response, providing an explanation for the reduced hsp70 response in the old rats. A variety of vasoactive agents that induce acute hypertension through distinct signal transduction pathways, including phenylephrine, dopamine, vasopressin, angiotensin II, and endothelin-1, were found to result in hsp70 mRNA induction in the aorta. The magnitude of hsp70 expression achieved with these hypertensive agents was directly correlated with their relative effects on blood pressure. Rats were treated with the vasodilator sodium nitroprusside, which prevented an acute rise in blood pressure from the hypertensive agents tested and abolished induction of hsp70 expression. CONCLUSIONS: These findings support the conclusion that hsp70 induction occurs as a physiological response to acute hypertension and suggest the possibility that hsp70 plays a role in the protecting the vasculature from damage during hemodynamic stress.
Q Xu; D G Li; N J Holbrook; R Udelsman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  92     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1995-09-25     Completed Date:  1995-09-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1223-9     Citation Subset:  AIM; IM; S    
Section on Gene Expression and Aging, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
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MeSH Terms
Aging / metabolism,  physiology
Aorta / metabolism
Gene Expression
HSP70 Heat-Shock Proteins / biosynthesis*,  genetics
Hypertension / drug therapy,  metabolism*,  physiopathology
Muscle, Smooth, Vascular / metabolism*
Nitroprusside / pharmacology
RNA, Messenger / genetics
Rats, Inbred F344
Rats, Inbred SHR
Rats, Inbred WKY
Restraint, Physical
Stress, Physiological / metabolism*,  physiopathology
Grant Support
Reg. No./Substance:
0/HSP70 Heat-Shock Proteins; 0/RNA, Messenger; 15078-28-1/Nitroprusside

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