| Acute hypertension in intracerebral hemorrhage: pathophysiology and treatment. | |
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MedLine Citation:
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PMID: 17550786 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Non-traumatic or spontaneous intracerebral hemorrhage (ICH) is defined as intra-parenchymal bleeding with or without extension into the ventricles and rarely into the subarachoid space. Primary ICH in most cases is associated with chronic hypertension. Acute hypertension is associated with hematoma expansion, and poor neurological outcome. The treatment of hypertension in acute ICH is a topic of controversy. Experiments have shown an area of ischemia around the hematoma, with the reduction of regional cerebral blood flow (CBF) secondary to compression of microvasculature. Not all scientific results agree with the above findings. Recent studies have shown that CBF decreases in the perihematoma region but with concomitant reduction of cerebral metabolism, which would argue against an area of ischemia in the perihematoma region. Based on the above result, there have been several clinical trials looking at clinical outcome and decrease in hematoma expansion rates with reduction of blood pressure acutely after ICH. The parameters for the blood pressure control are still under investigation. The American Heart Association has put forward guidelines for blood pressure control which have been adopted in the centers around the country. We have described the protocol we use at our center for the blood pressure control in patients with acute ICH. |
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Authors:
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Qaisar A Shah; Mustapha A Ezzeddine; Adnan I Qureshi |
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Publication Detail:
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Type: Journal Article; Review Date: 2007-06-05 |
Journal Detail:
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Title: Journal of the neurological sciences Volume: 261 ISSN: 0022-510X ISO Abbreviation: J. Neurol. Sci. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-09-03 Completed Date: 2007-11-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 74-9 Citation Subset: IM |
Affiliation:
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Zeenat Qureshi Stroke Research Center, Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA. qaisarshah@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease American Hospital Association Antihypertensive Agents / therapeutic use Cerebral Hemorrhage / complications, drug therapy, physiopathology* Cerebrovascular Circulation Clinical Trials as Topic Humans Hypertension / complications*, drug therapy, physiopathology* United States |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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