Document Detail

Acute hypertension in intracerebral hemorrhage: pathophysiology and treatment.
MedLine Citation:
PMID:  17550786     Owner:  NLM     Status:  MEDLINE    
Non-traumatic or spontaneous intracerebral hemorrhage (ICH) is defined as intra-parenchymal bleeding with or without extension into the ventricles and rarely into the subarachoid space. Primary ICH in most cases is associated with chronic hypertension. Acute hypertension is associated with hematoma expansion, and poor neurological outcome. The treatment of hypertension in acute ICH is a topic of controversy. Experiments have shown an area of ischemia around the hematoma, with the reduction of regional cerebral blood flow (CBF) secondary to compression of microvasculature. Not all scientific results agree with the above findings. Recent studies have shown that CBF decreases in the perihematoma region but with concomitant reduction of cerebral metabolism, which would argue against an area of ischemia in the perihematoma region. Based on the above result, there have been several clinical trials looking at clinical outcome and decrease in hematoma expansion rates with reduction of blood pressure acutely after ICH. The parameters for the blood pressure control are still under investigation. The American Heart Association has put forward guidelines for blood pressure control which have been adopted in the centers around the country. We have described the protocol we use at our center for the blood pressure control in patients with acute ICH.
Qaisar A Shah; Mustapha A Ezzeddine; Adnan I Qureshi
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-06-05
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  261     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-03     Completed Date:  2007-11-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  74-9     Citation Subset:  IM    
Zeenat Qureshi Stroke Research Center, Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA.
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MeSH Terms
Acute Disease
American Hospital Association
Antihypertensive Agents / therapeutic use
Cerebral Hemorrhage / complications,  drug therapy,  physiopathology*
Cerebrovascular Circulation
Clinical Trials as Topic
Hypertension / complications*,  drug therapy,  physiopathology*
United States
Reg. No./Substance:
0/Antihypertensive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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