Document Detail


Acute hyperoxic injury attenuates the relaxing effects of "loop" diuretics and salbutamol on large airways of newborn guinea pigs.
MedLine Citation:
PMID:  7494647     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have previously found an age-dependent relaxing effect of furosemide in normal fetal, newborn, and adult guinea pig airways with fetal trachea exhibiting the greatest relaxation and adult tissue the least. This study was designed to expand upon this finding by determining if in vivo hyperoxic exposure would influence in vitro airway relaxation mediated by the loop diuretics, furosemide and ethacrynic acid, and the beta 2-adrenoceptor agonist, salbutamol. Newborn guinea pigs were raised in > 95% FiO2 until ill; controls in room air. Isometric relaxation to 3 x 10(-5) M furosemide, 3 x 10(-6) M ethacrynic acid, or 10(-8)-10(-6) M salbutamol was recorded in 3 x 10(-6) M histamine-constricted airway rings. Ethacrynic acid, like furosemide, relaxed newborn guinea pig airways. Hyperoxia did not alter the contractile effect of 3 x 10(-6) M histamine but did significantly decrease the relaxing effect of furosemide, ethacrynic acid, and salbutamol. Loop diuretic mediated airway relaxation was accentuated in HEPES buffer when compared with Krebs, whereas salbutamol-mediated relaxation was unaffected. These results suggest that hyperoxia nonspecifically decreases airway responsiveness to the relaxing agents studied.
Authors:
G A Marinkovich; B E Pichoff; L M Iwamoto; M V Dressel; K T Nakamura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatric research     Volume:  38     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1996-01-11     Completed Date:  1996-01-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  280-5     Citation Subset:  IM    
Affiliation:
Department of Clinical Investigation, Tripler Army Medical Center, TAMC, Hawaii 96859, USA.
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MeSH Terms
Descriptor/Qualifier:
Albuterol / pharmacology*
Animals
Animals, Newborn
Bronchi / drug effects*,  physiology
Bronchodilator Agents / pharmacology*
Diuretics / pharmacology*
Ethacrynic Acid / pharmacology
Female
Guinea Pigs
Hyperoxia / physiopathology*
Male
Muscle Relaxation / drug effects
Time Factors
Trachea / drug effects*,  physiology
Grant Support
ID/Acronym/Agency:
HL-45220/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Bronchodilator Agents; 0/Diuretics; 18559-94-9/Albuterol; 58-54-8/Ethacrynic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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