| Acute hyperinsulinemia is followed by increased serum concentrations of fibroblast growth factor 23 in type 2 diabetes patients. | |
| | |
MedLine Citation:
|
PMID: 22133206 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background. Phosphate homeostasis is connected to glucose metabolism and is influenced by insulin, but the role of fibroblast growth factor 23 (FGF23) is unknown in this relation. Therefore, the levels of FGF23 and phosphate were investigated during a euglycemic-hyperinsulinemic clamp in healthy and type 2 diabetic individuals. Methods. The study population consisted of ten type 2 diabetic patients, ten weight-matched glucose-tolerant obese subjects, and ten healthy lean subjects. All subjects underwent a 4-h euglycemic-hyperinsulinemic clamp using physiological hyperinsulinemia (40 mU/min per m(2)) to determine glucose disposal rates. Blood samples for measurement of serum FGF23 and insulin, plasma phosphate and glucose, and HbA(1c) were drawn before and after insulin infusion. Results. The three groups did not differ in baseline levels of serum FGF23. Insulin infusion increased serum FGF23 in the diabetic group (p = 0.009), but not in the other groups. The increase in serum FGF23 correlated strongly with increase in insulin levels in the diabetic group (r = 0.83; p = 0.003). In the overall group insulin infusion suppressed plasma phosphate concentrations (p = 0.006), but with no differences between the groups. Conclusions. Physiological hyperinsulinemia is under euglycemic conditions followed by a significant increase in serum FGF23 concentrations in diabetic individuals, which correlated with change in insulin level. The interplay between insulin effects and FGF23 may be important for the understanding of phosphate metabolism in relation to type 2 diabetes and its vascular complications. |
| | |
Authors:
|
Kristian Winther; Mads Nybo; Birgitte Vind; Susanne Møller Pedersen; Kurt Højlund; Lars Melholt Rasmussen |
Related Documents
:
|
2646586 - Ultrasound demonstration of prenatal renal vein thrombosis. 63656 - Subcutaneous fat in newborn infants of diabetic mothers: an indication of quality of di... 6385716 - What affects fetal pulmonary maturation during diabetic pregnancy? 6751016 - Continuous maternal glucose measurements and fetal glucose and insulin levels after adm... 8476236 - Role of insulin resistance in human disease (syndrome x): an expanded definition. 18309686 - Differences in insulin sensitivity and secretory capacity based on ogtt in subjects wit... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-1 |
Journal Detail:
|
Title: Scandinavian journal of clinical and laboratory investigation Volume: - ISSN: 1502-7686 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-2 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0404375 Medline TA: Scand J Clin Lab Invest Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Clinical Biochemistry and Pharmacology. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Allelic variant of NOS1AP effects on cardiac alternans of repolarization during exercise testing.
Next Document: Elderly cases of Churg-Strauss syndrome: Case report and review of Japanese cases.