| Acute hyperinsulinemia decreases plasma osteoprotegerin with diminished effect in type 2 diabetes and obesity. | |
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MedLine Citation:
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PMID: 19380455 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Osteoprotegerin (OPG) is a soluble tumour necrosis factor-receptor-like molecule present in connective tissues, especially bone and vasculature. It is known to accumulate in the arterial wall in diabetes. As its synthesis in vascular cells is decreased by insulin, we wanted to elucidate the acute effects of insulin on plasma OPG concentrations in individuals with type 2 diabetes and obese individuals compared with lean controls. DESIGN: The study population consisted of ten type 2 diabetic, ten obese subjects, and ten lean subjects with no family history of diabetes. METHODS: All subjects underwent a 4-h euglycemic-hyperinsulinemic clamp. Plasma OPG, insulin, lactate, HbA1c, cholesterol, triglycerides, free fatty acids (FFA), and glucose disposal rate were measured before and at the end of the clamp. RESULTS: Baseline OPG concentrations did not differ significantly between groups. Insulin infusion decreased plasma OPG concentrations in all groups (P<0.01); however, the fall in OPG was 50% less in obese and type 2 diabetic individuals (P=0.007). Baseline OPG correlated with fasting insulin, baseline lactate, and low density lipoprotein cholesterol in the diabetic group, and with baseline FFA in the lean group. The relative change of OPG in response to insulin correlated inversely with HbA1c and baseline FFA in the lean group. CONCLUSIONS: Acute hyperinsulinemia decreases plasma OPG, but with diminished effect in individuals with type 2 diabetes and obesity. Increased levels of OPG in arteries and plasma in diabetes together with the capability of plasma OPG as a cardiovascular risk predictor may be related to the described effects of insulin. |
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Authors:
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Gitte Maria Jørgensen; Birgitte Vind; Mads Nybo; Lars Melholt Rasmussen; Kurt Højlund |
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Publication Detail:
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Type: Journal Article Date: 2009-04-20 |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: 161 ISSN: 1479-683X ISO Abbreviation: Eur. J. Endocrinol. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-29 Completed Date: 2009-07-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 95-101 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Pharmacology and Genetics, Odense University Hospital, Sdr. Boulevard 29, DK-5000 Odense, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Body Weight Cardiovascular Diseases / epidemiology, metabolism Diabetes Mellitus, Type 2 / epidemiology, metabolism* Female Glucose Clamp Technique Humans Hyperinsulinism / epidemiology, metabolism* Insulin / blood Male Middle Aged Obesity / epidemiology, metabolism* Osteoprotegerin / blood* Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Osteoprotegerin; 0/TNFRSF11B protein, human; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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