| Acute hyperhomocysteinaemia affects pulse pressure but not microvascular vasodilator function. | |
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MedLine Citation:
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PMID: 11560567 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Raised homocysteine (hcy) levels are associated with premature coronary artery disease, but the underlying vascular mechanism and the extent to which hcy affects small vessel vasodilator responses (especially non-nitric oxide mediated pathways) are unclear. METHODS: This double-blind, placebo-controlled crossover study in 14 healthy male subjects evaluated the effects of single-dose oral methionine 15 g (to induce acute hyperhomocysteinaemia) on cutaneous microvascular vasodilator responses to incremental-dose iontophoretic administration of acetylcholine (Ach) and sodium nitroprusside (SNP) using laser Doppler fluximetry (LDF), and the effects on von Willibrand factor (vWF) levels and systemic haemodynamics. RESULTS: Methionine administration produced a three fold rise in plasma hcy levels at 8 h, which was accompanied by a significant increase in pulse pressure (53 vs 49 mmHg, P < 0.05) but no change in heart rate. Acute hyperhomocysteinaemia had no significant effect on incremental microvascular vasodilator dose-response curves to Ach and SNP, or circulating levels of vWF. CONCLUSIONS: The present study shows that acute hyperhomocysteinaemia increases pulse pressure (a marker of large vessel stiffness) but has no effect on endothelial-dependent (non-NO-mediated) microvascular vasodilation. |
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Authors:
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K R Davis; H Pearson; S Moat; J R Bonham; R Donnelly |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: 52 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 2001 Sep |
Date Detail:
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Created Date: 2001-09-18 Completed Date: 2001-10-11 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 327-32 Citation Subset: IM |
Affiliation:
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School of Medical and Surgical Sciences, University of Nottingham, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology Administration, Oral Adult Blood Pressure / drug effects Blood Vessels / drug effects, physiology* Cross-Over Studies Double-Blind Method Heart Rate / drug effects Homocysteine / blood*, drug effects Humans Laser-Doppler Flowmetry Male Methionine / pharmacology Nitroprusside / pharmacology Pressure Pulse* Skin / blood supply Vasodilation / drug effects, physiology* Vasodilator Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 15078-28-1/Nitroprusside; 454-28-4/Homocysteine; 51-84-3/Acetylcholine; 63-68-3/Methionine |
| Comments/Corrections | |
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