Document Detail

Acute hypercalcemia and increased work load in canine transplanted heart. Coronary blood flow adjustments.
MedLine Citation:
PMID:  2265649     Owner:  NLM     Status:  MEDLINE    
Coronary vasodilator adjustments following cardiac transplantation might be adversely affected during severe rejection. We studied the coronary blood flow response following intravenous bolus administration of calcium (0.04-0.05 mEq/kg) in canine cardiac transplants. Fifteen dogs were submitted to orthotopic heart transplantation and equipped with electronic implants for monitoring of hemodynamic parameters. Of these animals, 9 were not immunosuppressed, while 6 were treated with ciclosporin, azathioprine, and prednisone. The effects of calcium administration upon cardiac function were evaluated during the postoperative period, at recovery (2-3 days after transplantation) and during severe rejection (7-10 days after transplantation), and also in immunosuppressed animals. Rapid calcium administration elicits brief increases in arterial pressure, cardiac index, stroke work, and coronary blood flow. There were significant differences in these effects, depending on the hemodynamic status of these animals. Coronary blood flow was significantly increased in all experiments, except when severe rejection was evidenced. These results indicate that changes in myocardial metabolic demand (work load) are not adequately matched with coronary blood flow adjustments in the presence of severe rejection.
L Dumont; C Chartrand
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes     Volume:  22     ISSN:  0014-312X     ISO Abbreviation:  Eur Surg Res     Publication Date:  1990  
Date Detail:
Created Date:  1991-02-11     Completed Date:  1991-02-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0174752     Medline TA:  Eur Surg Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  128-35     Citation Subset:  IM    
Département de Pharmacologie, Faculté de Médecine, Université de Montréal, Qué., Canada.
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MeSH Terms
Acute Disease
Calcium / pharmacology
Coronary Circulation*
Graft Rejection
Heart / physiopathology*
Heart Transplantation / adverse effects*
Hemodynamics / drug effects
Hypercalcemia / etiology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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